High-resolution Computed Tomography for Clinical Imaging of Bone Microarchitecture
Open Access
- 23 February 2011
- journal article
- review article
- Published by Ovid Technologies (Wolters Kluwer Health) in Clinical Orthopaedics & Related Research
- Vol. 469 (8), 2179-2193
- https://doi.org/10.1007/s11999-010-1766-x
Abstract
Background The role of bone structure, one component of bone quality, has emerged as a contributor to bone strength. The application of high-resolution imaging in evaluating bone structure has evolved from an in vitro technology for small specimens to an emerging clinical research tool for in vivo studies in humans. However, many technical and practical challenges remain to translate these techniques into established clinical outcomes. Questions/purposes We reviewed use of high-resolution CT for evaluating trabecular microarchitecture and cortical ultrastructure of bone specimens ex vivo, extension of these techniques to in vivo human imaging studies, and recent studies involving application of high-resolution CT to characterize bone structure in the context of skeletal disease. Methods We performed the literature review using PubMed and Google Scholar. Keywords included CT, MDCT, micro-CT, high-resolution peripheral CT, bone microarchitecture, and bone quality. Results Specimens can be imaged by micro-CT at a resolution starting at 1 μm, but in vivo human imaging is restricted to a voxel size of 82 μm (with actual spatial resolution of ~ 130 μm) due to technical limitations and radiation dose considerations. Presently, this mode is limited to peripheral skeletal regions, such as the wrist and tibia. In contrast, multidetector CT can assess the central skeleton but incurs a higher radiation burden on the subject and provides lower resolution (200–500 μm). Conclusions CT currently provides quantitative measures of bone structure and may be used for estimating bone strength mathematically. The techniques may provide clinically relevant information by enhancing our understanding of fracture risk and establishing the efficacy of antifracture for osteoporosis and other bone metabolic disorders.Keywords
This publication has 138 references indexed in Scilit:
- Radiation exposure in X-ray-based imaging techniques used in osteoporosisEuropean Radiology, 2010
- Strontium ranelate and alendronate have differing effects on distal tibia bone microstructure in women with osteoporosisRheumatology International, 2010
- Beam hardening artifacts in micro-computed tomography scanning can be reduced by X-ray beam filtration and the resulting images can be used to accurately measure BMDBone, 2009
- Hormone predictors of abnormal bone microarchitecture in women with anorexia nervosaBone, 2009
- Assessment of trabecular bone structure using MDCT: comparison of 64- and 320-slice CT using HR-pQCT as the reference standardEuropean Radiology, 2009
- Age- and gender-dependent changes in three-dimensional microstructure of cortical and trabecular bone at the human femoral neckOsteoporosis International, 2009
- Assessment of trabecular and cortical architecture and mechanical competence of bone by high-resolution peripheral computed tomography: comparison with transiliac bone biopsyOsteoporosis International, 2009
- Automated simulation of areal bone mineral density assessment in the distal radius from high-resolution peripheral quantitative computed tomographyOsteoporosis International, 2009
- Quantitative Assessment of Bone Tissue Mineralization with Polychromatic Micro-Computed TomographyCalcified Tissue International, 2008
- Resolution Dependence of the Non-metric Trabecular Structure IndicesBone, 2008