Treatment of schistosomiasis in African infants and preschool-aged children: downward extension and biometric optimization of the current praziquantel dose pole
Open Access
- 30 June 2012
- journal article
- Published by Oxford University Press (OUP) in International Health
- Vol. 4 (2), 95-102
- https://doi.org/10.1016/j.inhe.2012.03.003
Abstract
To facilitate administration of praziquantel (PZQ) to African infants and preschool-aged children using a dose pole, the performance of two downwardly extended versions (the first created in 2010 using biometric data from Uganda alone and the second version created here using data from 36 countries) was assessed against height/weight data from a total of 166 210 preschool-aged children (≤6 year olds) from 36 African countries. New and optimized thresholds for PZQ tablet administration at one tablet (600 mg), ¾ and ½ tablet divisions are suggested here. Both dose poles investigated estimated an acceptable PZQ dosage (30–60 mg/Kg) for more than 95% of children. Extension and optimization of the current PZQ dose pole, followed by theoretical validation using biometric data from preschool-aged children (0–6 years of age, 60–110 cm in height) from 36 African countries will help future mass drug administration campaigns incorporate younger children. This newly optimized dose pole with single 600 mg (height: 99–110 cm), ¾ (height: 83–99 cm) and ½ (height: 66–83 cm) tablet divisions, also reduces drug waste and facilitates inclusion of preschool-aged children. Our findings also have bearings on the use of other dose poles for treatment of young children.Keywords
This publication has 39 references indexed in Scilit:
- Closing the praziquantel treatment gap: new steps in epidemiological monitoring and control of schistosomiasis in African infants and preschool-aged childrenParasitology, 2011
- Field survey for strongyloidiasis in eastern Uganda with observations on efficacy of preventive chemotherapy and co-occurrence of soil-transmitted helminthiasis/intestinal schistosomiasisJournal of Helminthology, 2010
- Treatment of intestinal schistosomiasis in Ugandan preschool children: best diagnosis, treatment efficacy and side-effects, and an extended praziquantel dosing poleInternational Health, 2010
- RESISTING CONTROL OF NEGLECTED TROPICAL DISEASES: DILEMMAS IN THE MASS TREATMENT OF SCHISTOSOMIASIS AND SOIL-TRANSMITTED HELMINTHS IN NORTH-WEST UGANDAJournal of Biosocial Science, 2008
- Leave children untreated and sustain inequity!Trends in Parasitology, 2007
- Waterborne Infectious Diseases—Could They Be Consigned to History?Science, 2006
- The control of schistosomiasis and soil-transmitted helminths in East AfricaTrends in Parasitology, 2006
- Efficacy and side-effects of two praziquantel treatments againstSchistosoma haematobiuminfection, among schoolchildren from Côte d'IvoirePathogens and Global Health, 2003
- Can prevalence of infection in school-aged children be used as an index for assessing community prevalence?Parasitology, 1999
- On the Interpretation of χ 2 from Contingency Tables, and the Calculation of PJournal of the Royal Statistical Society, 1922