Effect of apolipoprotein E genotype on in-hospital mortality following intracerebral haemorrhage
- 12 February 2003
- journal article
- research article
- Published by Hindawi Limited in Acta Neurologica Scandinavica
- Vol. 107 (2), 106-109
- https://doi.org/10.1034/j.1600-0404.2003.01365.x
Abstract
To determine the relationship between the apolipoprotein E (APOE) epsilon4 allele and in-hospital mortality from intracerebral haemorrhage (ICH). Patients admitted to two acute stroke units with ICH were prospectively evaluated and APOE genotyped. In-hospital survival was recorded in 176 patients. There were 85 men and 91 women, mean age 68 years. Fifty-two (30%) of the 176 patients died in hospital. After adjusting for sex, age, hospital, and race, increased age (P = 0.009) and the presence of the APOEepsilon4 allele (P = 0.026) significantly reduced in-hospital survival. The APOEepsilon4 allele in this population may be associated with poor survival following ICH.Keywords
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