Epithelial decision makers: in search of the 'epimmunome'
- 20 July 2010
- journal article
- review article
- Published by Springer Science and Business Media LLC in Nature Immunology
- Vol. 11 (8), 656-665
- https://doi.org/10.1038/ni.1905
Abstract
Frequent microbial and nonmicrobial challenges to epithelial cells trigger discrete pathways, promoting molecular changes such as the secretion of specific cytokines and chemokines and alterations to molecules displayed at the epithelial cell surface. In combination, these molecules impose key decisions on innate and adaptive immune cells. Depending on context, those decisions can be as diverse as those imposed by professional antigen-presenting cells, benefiting the host by balancing immune competence with the avoidance of immunopathology. Nonetheless, this potency of epithelial cells is also consistent with the causal contribution of epithelial dysregulation to myriad inflammatory diseases. This pathogenic axis provides an attractive target for tissue-specific clinical manipulation. In this context, a research goal should be to identify all molecules used by epithelial cells to instruct immune cells. We term this the 'epimmunome'.Keywords
This publication has 115 references indexed in Scilit:
- The NLRP3 Inflammasome Protects against Loss of Epithelial Integrity and Mortality during Experimental ColitisImmunity, 2010
- Interferon-γ Regulates Intestinal Epithelial Homeostasis through Converging β-Catenin Signaling PathwaysImmunity, 2010
- Lymphotoxin Beta Receptor Signaling in Intestinal Epithelial Cells Orchestrates Innate Immune Responses against Mucosal Bacterial InfectionImmunity, 2010
- The InflammasomesCell, 2010
- Induction of Intestinal Th17 Cells by Segmented Filamentous BacteriaCell, 2009
- Regulation of costimulation in the era of butyrophilinsCytokine, 2009
- XBP1 Links ER Stress to Intestinal Inflammation and Confers Genetic Risk for Human Inflammatory Bowel DiseaseCell, 2008
- Beyond inflammation: airway epithelial cells are at the interface of innate and adaptive immunityCurrent Opinion in Immunology, 2007
- Epithelium: At the interface of innate and adaptive immune responsesJournal of Allergy and Clinical Immunology, 2007
- Thymic selection threshold defined by compartmentalization of Ras/MAPK signallingNature, 2006