Ultrasound ionization of biomolecules
- 27 July 2010
- journal article
- research article
- Published by Wiley in Rapid Communications in Mass Spectrometry
- Vol. 24 (17), 2569-2574
- https://doi.org/10.1002/rcm.4677
Abstract
To date, mass spectrometric analysis of biomolecules has been primarily performed with either matrix-assisted laser desorption/ionization (MALDI) or electrospray ionization (ESI). In this work, ultrasound produced by a simple piezoelectric device is shown as an alternative method for soft ionization of biomolecules. Precursor ions of proteins, saccharides and fatty acids showed little fragmentation. Cavitation is considered as a primary mechanism for the ionization of biomolecules. Copyright © 2010 John Wiley & Sons, Ltd.Keywords
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