Neutrophil‐mediated vascular barrier injury: Role of neutrophil extracellular traps
- 25 April 2017
- journal article
- review article
- Published by Wiley in Microcirculation
- Vol. 24 (3)
- https://doi.org/10.1111/micc.12352
Abstract
Neutrophils play an essential role in host defense against infection or injury. While neutrophil activation is necessary for pathogen clearance and tissue repair, a hyperactive response can lead to tissue damage and microcirculatory disorders, a process involving complex neutrophil-endothelium cross talk. This review highlights recent research findings about neutrophil-mediated signaling and structural changes, including those induced by neutrophil extracellular traps, which ultimately lead to vascular barrier injury.Keywords
Funding Information
- National Institutes of Health (HL070752, HL126646)
This publication has 119 references indexed in Scilit:
- Neutrophil histone modification by peptidylarginine deiminase 4 is critical for deep vein thrombosis in miceProceedings of the National Academy of Sciences of the United States of America, 2013
- Plasmodium falciparum Histones Induce Endothelial Proinflammatory Response and Barrier DysfunctionThe American Journal of Pathology, 2012
- Role of reactive oxygen and nitrogen species in the vascular responses to inflammationFree Radical Biology & Medicine, 2011
- Stabilizing the VE-cadherin-catenin complex blocks leukocyte extravasation and vascular permeabilityThe EMBO Journal, 2011
- Neutrophil transmigration, focal adhesion kinase and endothelial barrier functionMicrovascular Research, 2011
- Endogenous histones function as alarmins in sterile inflammatory liver injury through Toll‐like receptor 9 in miceHepatology, 2011
- Opening the flood-gates: how neutrophil-endothelial interactions regulate permeabilityTrends in Immunology, 2009
- Extracellular histones are major mediators of death in sepsisNature Medicine, 2009
- Molecular mechanisms of endothelial hyperpermeability: implications in inflammationExpert Reviews in Molecular Medicine, 2009
- Getting to the site of inflammation: the leukocyte adhesion cascade updatedNature Reviews Immunology, 2007