Particle Characteristics and Biodistribution of Camptothecin-Loaded PLA/(PEG-PPG-PEG) Nanoparticles
- 1 January 2008
- journal article
- Published by Informa UK Limited in Drug Delivery
- Vol. 15 (1), 3-10
- https://doi.org/10.1080/10717540701827154
Abstract
Poly(DL-lactic acid) (PLA)/poly(ethylene glycol)-block-poly (propylene glycol)-block-poly(ethylene glycol) copolymer (PEG-PPG-PEG) nanoparticles loaded with camptothecin (CPT), called CPT-NP, were prepared and examined for particle size change and drug release in phosphate-buffered saline, pH 7.4, (PBS), and drug biodistribution profiles in mice bearing sarcoma 180 solid tumor. CPT-NP kept an almost constant mean size and exhibited an initial rapid release of approximately 20%, following by very slow release. As compared with CPT solution, CPT-NP showed higher tissue accumulation and better tumor localization, which were considered essentially associated with the better efficacy of CPT-NP reported in the previous study.Keywords
This publication has 22 references indexed in Scilit:
- Treatment of experimental arthritis with poly(D, L-lactic/glycolic acid) nanoparticles encapsulating betamethasone sodium phosphateAnnals Of The Rheumatic Diseases, 2005
- Antitumor characteristics of methoxypolyethylene glycol–poly(dl-lactic acid) nanoparticles containing camptothecinJournal of Controlled Release, 2004
- Glycyrrhetic acid-loaded microparticles: liver-specific delivery and therapeutic potential against carbon tetrachloride-induced hepatitisJournal of Pharmacy and Pharmacology, 2004
- Pharmacokinetics of prolonged-release CPT-11-loaded microspheres in ratsJournal of Controlled Release, 2000
- Antitumor effect of liposome-incorporated camptothecin in human malignant xenograftsAnti-Cancer Drugs, 1995
- Metabolic Activation of CPT-11, 7-Ethyl-10-(4-(1-piperidino)-1-piperidino)carbonyloxycamptothecin, a Novel Antitumor Agent, by Carboxylesterase.Biological & Pharmaceutical Bulletin, 1994
- CPT-11 Converting Enzyme from Rat Serum: Purification and Some Properties.Journal of Pharmacobio-Dynamics, 1991
- In vivo release profiles of leuprolide acetate from microcapsules prepared with polylactic acids or copoly(lactic/glycolic) acids and in vivo degradation of these polymers.CHEMICAL & PHARMACEUTICAL BULLETIN, 1988
- Preparation and evaluation in vitro and in vivo of polylactic acid microspheres containing doxorubicin.CHEMICAL & PHARMACEUTICAL BULLETIN, 1985
- Plant Antitumor Agents. I. The Isolation and Structure of Camptothecin, a Novel Alkaloidal Leukemia and Tumor Inhibitor from Camptotheca acuminata1,2Journal of the American Chemical Society, 1966