Characteristics of melanoma in Japan: a nationwide registry analysis 2011–2013
- 1 October 2017
- journal article
- review article
- Published by Ovid Technologies (Wolters Kluwer Health) in Melanoma Research
- Vol. 27 (5), 492-497
- https://doi.org/10.1097/cmr.0000000000000375
Abstract
The distribution and incidence of melanoma vary among different races and ethnic groups. This study aimed to investigate the characteristics of cutaneous melanoma, mucosal melanoma, uveal melanoma, and melanoma of unknown primary (MUP) origin in a Japanese population. We studied these four types of melanoma in patients registered in Hospital Based Cancer Registries in Japan from 2011 to 2013. A total of 5566 patients with melanoma were identified. The distribution of sex, age, primary site, and clinical stage was analyzed. The number of patients, proportion in comparison with all melanoma cases, and crude incidence rate per 100 000 person-year of each melanoma type were 4481, 80.5%, and 1.24 in invasive cutaneous; 821, 14.8%, and 0.32 in mucosal; 163, 2.9%, and 0.064 in uveal; and 101, 1.8%, and 0.039 in MUP origin, respectively. Including the patients with in-situ cutaneous melanoma and stage unknown cutaneous melanoma, the crude incidence rate of cutaneous melanoma increased at 1.75. Almost half of the cutaneous melanomas were located in the lower limb. Cutaneous melanoma was the most common, but less frequent than that in western countries. Mucosal melanoma was quite rare, but its proportion and crude incidence rate were higher than those in western countries. Uveal melanoma was particularly rare, and its crude incidence rate was lower than that in western countries. MUP origin was also particularly rare, but it had almost the same incidence rate as that in other countries. Melanoma in Japan was heterogeneous among the four melanoma types and shares some attributes with that in western countries.Keywords
This publication has 30 references indexed in Scilit:
- Genetic markers of pigmentation are novel risk loci for uveal melanomaScientific Reports, 2016
- The National Database of Hospital-based Cancer Registries: A Nationwide Infrastructure to Support Evidence-based Cancer Care and Cancer Control Policy in JapanJapanese Journal of Clinical Oncology, 2013
- Mutations inGNA11in Uveal MelanomaNew England Journal of Medicine, 2010
- Cancer family history characterization in an unselected cohort of 121 patients with uveal melanomaFamilial Cancer, 2010
- Frequent somatic mutations of GNAQ in uveal melanoma and blue naeviNature, 2008
- Somatic Activation of KIT in Distinct Subtypes of MelanomaJournal of Clinical Oncology, 2006
- Distinct Sets of Genetic Alterations in MelanomaNew England Journal of Medicine, 2005
- Population-Based Incidence of Uveal Melanoma in Various Races and Ethnic GroupsAmerican Journal of Ophthalmology, 2005
- The National Cancer Data Base report on cutaneous and noncutaneous melanomaCancer, 1998
- Incidence of cutaneous melanoma among non-Hispanic Whites, Hispanics, Asians, and Blacks: an analysis of California Cancer Registry data, 1988-93Cancer Causes and Control, 1997