Preparation of thermo‐responsive polymer membranes. I
- 1 February 1991
- journal article
- research article
- Published by Wiley in Journal of Biomedical Materials Research
- Vol. 25 (2), 243-254
- https://doi.org/10.1002/jbm.820250210
Abstract
Two types of liquid crystal (LC)‐entrapped membranes, (a) polymer alloyed membranes and (b) LC‐adsorbed membranes, were investigated for the purpose of developing the drug delivery systems (DDS) with thermal stimuli responsing. Polymer alloyed membranes were obtained by polymerizing acrylic monomers in presence of LC and LC‐adsorbed membrane were obtained by adsorbing LC into porous hydrophobic polymer membrane. It was made clear from the indomethacin permeation experiments below and above the gel‐liquid crystal phase transition temperature of the LC that the extent of thermo‐sensitivity for LC‐adsorbed membranes was greater than that for the alloyed membrane. The permeability ratio (38°C vs. 32°C) was found to be about 120 with the LC‐adsorbed membrane. It was suggested from the results that the LC‐adsorbed membrane was one of the useful candidates as a thermo‐responsive system for DDS.Keywords
This publication has 13 references indexed in Scilit:
- Insulin permeation through thermo-sensitive hydrogelsJournal of Controlled Release, 1989
- Applications of thermally reversible polymers and hydrogels in therapeutics and diagnosticsJournal of Controlled Release, 1987
- Functional capsule membranes. 26. Permeability control of polymer-grafted capsule membranes responding to ambient pH changesMacromolecules, 1987
- "Complete" thermocontrol of ion permeation through ternary composite membranes composed of polymer/liquid crystal/amphiphilic crown ethersMacromolecules, 1987
- Penetration enhancing effect of Azone on the transport of 5-fluorouracil across the hairless rat skinInternational Journal of Pharmaceutics, 1986
- Lipid bilayer-corked capsule membranes. Reversible, signal-receptive permeation controlAccounts of Chemical Research, 1986
- Permeability of fluorescent probes at phase transitions from bilayer-coated capsule membranesJournal of the Chemical Society, Perkin Transactions 2, 1985
- Bilayer coated capsule membranes. Part 2. Photoresponsive permeability control of sodium chloride across a capsule membraneJournal of the Chemical Society, Perkin Transactions 2, 1984
- A large nylon capsule coated with a synthetic bilayer membrane. Permeability control of sodium chloride by phase transition of the dialkylammonium bilayer coatingJournal of the American Chemical Society, 1983
- A Glucose-Controlled Insulin-Delivery System: Semisynthetic Insulin Bound to LectinScience, 1979