Deep Brain Stimulation and Cognitive Decline in Parkinson’s Disease: A Clinical Review
Open Access
- 1 January 2012
- journal article
- review article
- Published by Frontiers Media SA in Frontiers in Neurology
- Vol. 3, 66
- https://doi.org/10.3389/fneur.2012.00066
Abstract
Parkinson’s disease (PD) is a common and often debilitating disorder, with a growing prevalence accompanying global population aging. Current drug therapy is not satisfactory enough for many patients, especially after a few years of symptom progression. This is mainly due to the motor complications that frequently emerge as disease progresses. Deep brain stimulation (DBS) is a useful therapeutic option in carefully selected patients that significantly improves motor symptoms, functional status and quality of life. However, cognitive impairment may limit patient selection for DBS, as patients need to have sufficient mental capabilities in order to understand the procedure, as well as its benefits and limitations, and cooperate with the medical team throughout the process of selection, surgery and postsurgical follow up. On the other hand it has been observed that certain aspects of cognitive performance may decline after DBS, namely when the therapeutic target is the widely used subthalamic nucleus. These are important pieces of information for patients, their families and health care professionals. This manuscript reviews these aspects and their clinical implications.This publication has 101 references indexed in Scilit:
- Cognitive outcome and reliable change indices two years following bilateral subthalamic nucleus deep brain stimulationParkinsonism & Related Disorders, 2011
- A recommended scale for cognitive screening in clinical trials of Parkinson's diseaseMovement Disorders, 2010
- Deep brain stimulation plus best medical therapy versus best medical therapy alone for advanced Parkinson's disease (PD SURG trial): a randomised, open-label trialThe Lancet Neurology, 2010
- Validity of the MoCA and MMSE in the detection of MCI and dementia in Parkinson diseaseNeurology, 2009
- Cognition and mood in Parkinson's disease in subthalamic nucleus versus globus pallidus interna deep brain stimulation: The COMPARE TrialAnnals of Neurology, 2009
- Bilateral Deep Brain Stimulation vs Best Medical Therapy for Patients With Advanced Parkinson DiseaseA Randomized Controlled TrialJAMA, 2009
- A multicentre study on suicide outcomes following subthalamic stimulation for Parkinson's diseaseBrain, 2008
- Stimulation of subterritories of the subthalamic nucleus reveals its role in the integration of the emotional and motor aspects of behaviorProceedings of the National Academy of Sciences of the United States of America, 2007
- Is there a dysexecutive syndrome?Philosophical Transactions B, 2007
- Projected number of people with Parkinson disease in the most populous nations, 2005 through 2030Neurology, 2007