Chagas Disease Transmission in Periurban Communities of Arequipa, Peru
Open Access
- 15 June 2008
- journal article
- Published by Oxford University Press (OUP) in Clinical Infectious Diseases
- Vol. 46 (12), 1822-1828
- https://doi.org/10.1086/588299
Abstract
Background. Chagas disease, caused by Trypanosoma cruzi infection, is an urban problem in Arequipa, Peru, and the epidemiology of Chagas disease is likely to be quite different in this area, compared with in rural zones. Methods. We conducted a serosurvey of 1615 children Results. Of 1615 children, 75 (4.7%) were infected with Trypanosoma cruzi. Infection risk increased by 12% per year of age, and children living in hillside shantytowns were 2.5 times as likely to be infected as were those living in lower-lying communities. However, age-prevalence data from 1 shantytown demonstrated that adults were no more likely to be seropositive than were teenagers; the results of maximum likelihood modeling suggest that T. cruzi transmission began in this community Conclusions. The problem of Chagas disease in periurban settings, such as those around Arequipa, must be addressed to achieve elimination of vector-borne T. cruzi transmission. Identification of infected children, vector-control efforts, and education to avoid modifiable risk factors are necessary to decrease the burden of Chagas disease.Keywords
This publication has 19 references indexed in Scilit:
- HOUSEHOLD RISK FACTORS FOR TRYPANOSOMA CRUZI SEROPOSITIVITY IN TWO GEOGRAPHIC REGIONS OF ECUADORJournal of Parasitology, 2007
- Long-Term Cardiac Outcomes of Treating Chronic Chagas Disease with Benznidazole versus No TreatmentAnnals of Internal Medicine, 2006
- SEROPREVALENCE AND RISK FACTORS FOR TRYPANOSOMA CRUZI INFECTION IN THE AMAZON REGION OF ECUADORThe American Journal of Tropical Medicine and Hygiene, 2003
- SEROPREVALENCE OF TRYPANOSOMA CRUZI INFECTION AMONG SCHOOL-AGE CHILDREN IN THE ENDEMIC AREA OF GUATEMALAThe American Journal of Tropical Medicine and Hygiene, 2003
- Modeling Household Transmission of American TrypanosomiasisScience, 2001
- Chagas disease in an area of recent occupation in Cochabamba, Bolivia.Revista de Saúde Pública, 1999
- Household prevalence of seropositivity for Trypanosoma cruzi in three rural villages in northwest Argentina: environmental, demographic, and entomologic associations.The American Journal of Tropical Medicine and Hygiene, 1998
- Efficacy of chemotherapy with benznidazole in children in the indeterminate phase of Chagas' disease.The American Journal of Tropical Medicine and Hygiene, 1998
- Randomised trial of efficacy of benznidazole in treatment of early Trypanosoma cruzi infectionThe Lancet, 1996
- Risk Factors for Trypanosoma cruzi Infection among Children in Central Brazil: A Case-Control Study in Vector Control SettingsThe American Journal of Tropical Medicine and Hygiene, 1995