Treatment of Brain Abscess Caused by Listeria monocytogenes in a Patient with Allergy to Penicillin and Trimethoprim-Sulfamethoxazole

Abstract
SIR—Listeria monocytogenes is an intracellular gram-positive rod that is known to cause systemic infection and CNS infection, primarily in patients with compromised cell-mediated immunity [1]. Treatment can be difficult, especially when infection involves the CNS, and there are a limited number of agents that are effective. We describe a patient with a brain abscess that was caused by L. monocytogenes who developed allergy to ampicillin and trimethoprim-sulfamethoxazole (TMP-SMZ) and who was successfully treated with a combination of linezolid and rifampin.