Skin Replacement Therapies for Diabetic Foot Ulcers
Open Access
- 1 April 2008
- journal article
- research article
- Published by American Diabetes Association in Diabetes Care
- Vol. 31 (4), 693-694
- https://doi.org/10.2337/dc07-2081
Abstract
Diabetic ulcer complications are a leading cause of hospitalization and amputation. Of the 20 million individuals with diabetes, 10–15% are at risk for developing diabetic ulcers. Standard therapy involves the use of dressings to protect the wound bed from trauma and to absorb exsudate; offloading high pressure from the wound bed, e.g., by prescribing protective footwear; and wound bed preparation to accelerate endogenous healing and facilitate the effectiveness of topically applied substances. But these measures are often deficient in healing all diabetic ulcers when the patient's own intrinsic wound-healing system is insufficient. In such patients, skin replacement therapies are second-line treatment options; however, the effectiveness of skin replacement therapies in treatment of diabetic ulcers is unclear. The objective of this study is to assess their effectiveness using evidence from randomized trials in diabetic leg and foot ulceration. We searched the Cochrane Controlled Trials Register (1970–2006), MEDLINE (1966–2006), EMBASE (1980–2006), and CINAHL (1982–2006) using a combination of text and keywords in addition to a filter for controlled clinical trials. The last update of searches was performed on 30 September 2007. We included trials if the allocation of participants was described as randomized, with participants of any age and in any care setting having diabetic leg or foot ulceration. We included studies that compared the following types of grafts with any other intervention: 1 ) autografts (pinch, split or full-thickness skin grafts, cultured keratinocytes, or fibroblasts), 2 ) allografts (cultured keratinocytes or fibroblasts), 3 ) xerografts, and 4 ) bioengineered skin. Two reviewers independently evaluated …Keywords
This publication has 7 references indexed in Scilit:
- The cell based dressing with living allogenic keratinocytes in the treatment of foot ulcers: a case studyBritish Journal of Plastic Surgery, 2005
- HYAFF 11-Based Autologous Dermal and Epidermal Grafts in the Treatment of Noninfected Diabetic Plantar and Dorsal Foot UlcersDiabetes Care, 2003
- Measuring inconsistency in meta-analysesBMJ, 2003
- The Efficacy and Safety of Dermagraft in Improving the Healing of Chronic Diabetic Foot UlcersDiabetes Care, 2003
- Graftskin, a Human Skin Equivalent, Is Effective in the Management of Noninfected Neuropathic Diabetic Foot UlcersDiabetes Care, 2001
- A Metabolically Active Human Dermal Replacement for the Treatment of Diabetic Foot UlcersArtificial Organs, 1997
- Use of Dermagraft, a Cultured Human Dermis, to Treat Diabetic Foot UlcersDiabetes Care, 1996