The concept of formulating a set of recommendations for patient management has its basis in the advent of scientific investigation in clinical medicine. Along with this came the realization that deriving recommendations from our own experience as clinicians, although tempting, has limitations related to the fact that humans remember the best or the worst of their experiences, and cannot easily objectify their results. What clinical experience does do for us is to help with the formulation of hypotheses that can be tested through human clinical trials experimentation. Rather than seeing clinical experience and clinical trials as dichotomous, polar sources of information regarding outcomes of patient care, it is probably more useful to think of the gamut of clinical testing along a continuum. On one end, we have the more-subjective impressions of care delivery that are attractive because they are grounded in personal experience in the real world of caring for...