Effects of Short-Term Treatment of Hyperlipidemia on Coronary Vasodilator Function and Myocardial Perfusion in Regions Having Substantial Impairment of Baseline Dilator Reverse

Abstract

Background —We tested the hypothesis that correction of hyperlipidemia improves coronary vasodilator response and maximal perfusion in myocardial regions having substantial impairment of pretreatment vasodilator capacity. Methods and Results —Measurements of myocardial blood flow were made with PET [ ¹³ N]ammonia in 12 patients with ischemic heart disease (11 men; age, 65±8 years [mean±SD]) at rest and during adenosine at 70 and then 140 μg · kg ⁻¹ · min ⁻¹ for 5 minutes each before and ≈4 months after simvastatin treatment (40 mg daily). Simvastatin reduced LDL (171±13 before versus 99±18 mg/dL after simvastatin, P P −1 · min ⁻¹ adenosine as normal (flow ≥2 mL · min ⁻¹ · g ⁻¹ ) or abnormal (flow −1 · g ⁻¹ ). In normal segments, baseline myocardial blood flow (0.95±0.32) increased ( P P P P P Conclusions —Short-term lipid-lowering therapy increases stenotic segment maximal myocardial blood flow by ≈45%. The mechanism involves enhanced, flow-mediated dilation of stenotic epicardial conduit vessels and may account at least in part for the efficacy of lipid lowering in secondary prevention trials and in reducing ischemic episodes in ambulatory patients.