Naltrexone and Coping Skills Therapy for Alcohol Dependence
- 1 November 1992
- journal article
- clinical trial
- Published by American Medical Association (AMA) in Archives of General Psychiatry
- Vol. 49 (11), 881-887
- https://doi.org/10.1001/archpsyc.1992.01820110045007
Abstract
• Ninety-seven alcohol-dependent patients were treated for 12 weeks in a double-blind, placebo-controlled study evaluating naltrexone and two manual guided psychotherapies in the treatment of alcohol dependence. Patients were randomized to receive either naltrexone or placebo and either coping skills/relapse prevention therapy or a supportive therapy designed to support the patient's own efforts at abstinence without teaching specific coping skills. Naltrexone proved superior to placebo in measures of drinking and alcohol-related problems, including abstention rates, number of drinking days, relapse, and severity of alcohol-related problems. Medication interacted with the type of psychotherapy received. The cumulative rate of abstinence was highest for patients treated with naltrexone and supportive therapy. For those patients who initiated drinking, however, patients who received naltrexone and coping skills therapy were the least likely to relapse.Keywords
This publication has 12 references indexed in Scilit:
- Tests of opioid deficiency hypotheses of alcoholismAlcohol, 1991
- Naltrexone and the Treatment of Alcohol-Dependence: Initial ObservationsPublished by Springer Science and Business Media LLC ,1990
- Potential Toxicities of High Doses of Naltrexone in Patients with Appetitive DisordersPublished by Springer Science and Business Media LLC ,1990
- National Institute of Mental Health Treatment of Depression Collaborative Research ProgramArchives of General Psychiatry, 1989
- Disulfiram treatment of alcoholism. A Veterans Administration cooperative studyPublished by American Medical Association (AMA) ,1986
- Naltrexone blocks the post-shock increase of ethanol consumptionLife Sciences, 1986
- Lifetime Prevalence of Specific Psychiatric Disorders in Three SitesArchives of General Psychiatry, 1984
- Veterans administration cooperative study of disulfiram in the treatment of alcoholism: Study design and methodological considerationsControlled Clinical Trials, 1984
- Renard Diagnostic InterviewArchives of General Psychiatry, 1981
- DEVELOPING A PROTOTYPE FOR EVALUATING ALCOHOL TREATMENT EFFECTIVENESSPublished by Elsevier BV ,1980