Transplantation of human umbilical vein endothelial cells improves left ventricular function in a rat model of myocardial infarction
- 3 February 2005
- journal article
- Published by Springer Science and Business Media LLC in Basic Research in Cardiology
- Vol. 100 (3), 208-216
- https://doi.org/10.1007/s00395-005-0516-9
Abstract
Although cell–based therapy after myocardial infarction (MI) may be beneficial in improving cardiac dysfunction, the underlying mechanisms remain to be clarified. Since human umbilical vein endothelial cells (HUVEC) harbor the potential for transdifferentiation, we studied the functional effects of HUVEC transplantation in a rat model of MI.This publication has 37 references indexed in Scilit:
- Haematopoietic stem cells adopt mature haematopoietic fates in ischaemic myocardiumNature, 2004
- A Different Outlook on the Role of Bone Marrow Stem Cells in Vascular GrowthCirculation Research, 2004
- Marrow-Derived Stromal Cells Express Genes Encoding a Broad Spectrum of Arteriogenic Cytokines and Promote In Vitro and In Vivo Arteriogenesis Through Paracrine MechanismsCirculation Research, 2004
- Bone marrow mononuclear cell therapy limits myocardial infarct size through vascular endothelial growth factorBasic Research in Cardiology, 2004
- Transplanted adult hematopoietic stems cells differentiate into functional endothelial cellsBlood, 2004
- Transdifferentiation of Blood-Derived Human Adult Endothelial Progenitor Cells Into Functionally Active CardiomyocytesCirculation, 2003
- Cardiomyocytes induce endothelial cells to trans-differentiate into cardiac muscle: Implications for myocardium regenerationProceedings of the National Academy of Sciences of the United States of America, 2001
- Local Implantation of Autologous Bone Marrow Cells for Therapeutic Angiogenesis in Patients With Ischemic Heart Disease. Clinical Trial and Preliminary Results.Japanese Circulation Journal, 2001
- Transplantation ofex vivoexpanded endothelial progenitor cells for therapeutic neovascularizationProceedings of the National Academy of Sciences of the United States of America, 2000
- Angiogenesis in cancer, vascular, rheumatoid and other diseaseNature Medicine, 1995