Applications of asymmetric organocatalysis in medicinal chemistry
Top Cited Papers
- 15 November 2012
- journal article
- review article
- Published by Royal Society of Chemistry (RSC) in Chemical Society Reviews
- Vol. 42 (2), 774-793
- https://doi.org/10.1039/c2cs35380f
Abstract
In the last decade, organocatalysis, the use of small chiral organic molecules as catalysts, has proven to be a valuable and attractive tool for the synthesis of enantiomerically enriched molecules. A number of organocatalysts and processes, such as one-pot, tandem, cascade or multicomponent reactions, have been reported to date. Furthermore, the many advantages of organocatalysis – robust, non-toxic, affordable, inert atmosphere, easy reaction manipulation, etc. – allow the preparation of bioactive compounds using simple and metal-free procedures, thus avoiding false positives in the biological evaluation. This mini-review focuses on medicinal chemistry programs that have synthesized biologically active compounds using one or more organocatalytic steps. In this respect, the potential of organocatalytic methods for enabling the chemical synthesis of important medicinal targets will be highlighted.This publication has 91 references indexed in Scilit:
- N‐Heterocyclic Carbene Catalyzed Domino ReactionsAngewandte Chemie, 2011
- Mechanisms in aminocatalysisChemical Communications, 2010
- Hydrogen Bonding in Organic SynthesisPublished by Wiley ,2009
- Small-Molecule H-Bond Donors in Asymmetric CatalysisChemical Reviews, 2007
- Metal-free organocatalysis through explicit hydrogen bonding interactionsChemical Society Reviews, 2003
- New Strategies for Organic Catalysis: The First Highly Enantioselective Organocatalytic Diels−Alder ReactionJournal of the American Chemical Society, 2000
- Asymmetric synthesis of bicyclic intermediates of natural product chemistryThe Journal of Organic Chemistry, 1974
- New Type of Asymmetric Cyclization to Optically Active Steroid CD Partial StructuresAngewandte Chemie, 1971
- Organische Katalysatoren. LXXI Asymmetrische Synthesen mit Ketenen. IV. Zusammenhänge zwischen dem räumlichen Bau einiger alkaloidartiger Katalysatoren und ihren stereospezifischen Wirkungen bei asymmetrischen EstersynthesenJournal für Praktische Chemie, 1964
- Organische Katalysatoren, LXI. Asymmetrische Synthesen mit Ketenen, I. Alkaloid‐katalysierte asymmetrische Synthesen von α‐Phenyl‐propionsäureesternEuropean Journal of Organic Chemistry, 1960