Regulatory Roles of Non-Coding RNAs in Colorectal Cancer
Open Access
- 21 August 2015
- journal article
- review article
- Published by MDPI AG in International Journal of Molecular Sciences
- Vol. 16 (8), 19886-19919
- https://doi.org/10.3390/ijms160819886
Abstract
Non-coding RNAs (ncRNAs) have recently gained attention because of their involvement in different biological processes. An increasing number of studies have demonstrated that mutations or abnormal expression of ncRNAs are closely associated with various diseases including cancer. The present review is a comprehensive examination of the aberrant regulation of ncRNAs in colorectal cancer (CRC) and a summary of the current findings on ncRNAs, including long ncRNAs, microRNAs, small interfering RNAs, small nucleolar RNAs, small nuclear RNAs, Piwi-interacting RNAs, and circular RNAs. These ncRNAs might become novel biomarkers and targets as well as potential therapeutic tools for the treatment of CRC in the near future and this review may provide important clues for further research on CRC and for the selection of effective therapeutic targets.Keywords
This publication has 192 references indexed in Scilit:
- Low expression of LOC285194 is associated with poor prognosis in colorectal cancerJournal of Translational Medicine, 2013
- Identification and Evaluation of Plasma MicroRNAs for Early Detection of Colorectal CancerPLOS ONE, 2013
- MicroRNA-32 (miR-32) regulates phosphatase and tensin homologue (PTEN) expression and promotes growth, migration, and invasion in colorectal carcinoma cellsMolecular Cancer, 2013
- MicroRNA-320a suppresses human colon cancer cell proliferation by directly targeting β-cateninBiochemical and Biophysical Research Communications, 2012
- Novel diagnostic value of circulating miR-18a in plasma of patients with pancreatic cancerBritish Journal of Cancer, 2011
- Dynamic interactions between transposable elements and their hostsNature Reviews Genetics, 2011
- The small-nucleolar RNAs commonly used for microRNA normalisation correlate with tumour pathology and prognosisBritish Journal of Cancer, 2011
- miR-126 Regulates Angiogenic Signaling and Vascular IntegrityDevelopmental Cell, 2008
- Resveratrol: A review of preclinical studies for human cancer preventionToxicology and Applied Pharmacology, 2007
- Finishing the euchromatic sequence of the human genomeNature, 2004