S-100 Protein and Neuron-Specific Enolase Concentrations in Blood as Indicators of Infarction Volume and Prognosis in Acute Ischemic Stroke
- 1 October 1997
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in Stroke
- Vol. 28 (10), 1956-1960
- https://doi.org/10.1161/01.str.28.10.1956
Abstract
Background and Purpose Better techniques are needed to monitor infarction volume and predict neurological outcome after ischemic brain infarction. We evaluated the usefulness of serial measurements of S-100 protein versus neuron-specific enolase (NSE) in blood samples from patients with acute stroke. Methods Using nonisotopic sandwich immunoassays, we measured plasma concentrations of S-100 protein and NSE on admission and on days 3, 4, 7, and 14 after infarction in 44 patients (age range, 22 to 86 years; mean age, 65.1 years; 12 female, 32 male). Infarct volume was measured by volumetric CT on day 4 after ictus, and clinical outcome was assessed at discharge from hospital with the Activities of Daily Living Scale and 6 months after infarction with the Glasgow Outcome Scale. Results Peak blood levels of S-100 protein were found on day 2.5±1.3, and peak levels of NSE were found on day 1.9±0.8 after infarction. Peak plasma levels of S-100 protein correlated well with infarct volume ( r =.75, P <.001) and with clinical outcome assessed with the Glasgow Outcome Scale ( r =.51, P <.001). Serum levels of NSE correlated with infarct volume ( r =.37, P <.05) but not with clinical outcome ( r =.18, P >.05). Conclusions The results of our study indicate that measuring blood concentrations of S-100 protein periodically in the first 10 days after cerebral infarction helps to predict infarct volume and the long-term neurological outcome more accurately than periodic measurements of blood concentrations of NSE.Keywords
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