Serum kallikrein-8 correlates with skin activity, but not psoriatic arthritis, in patients with psoriatic disease
- 22 August 2012
- journal article
- research article
- Published by Walter de Gruyter GmbH in cclm
- Vol. 51 (2), 317-325
- https://doi.org/10.1515/cclm-2012-0251
Abstract
Background:About 30% of cutaneous psoriasis (PsC) patients develop psoriatic arthritis (PsA) in the joint, which is under-recognized by dermatologists. Biomarkers for PsA are needed so that early referral to a rheumatologist is made. Kallikreins (KLKs) are secreted serine proteases implicated in skin desquamation and inflammation. This study examined KLK potential as serum biomarkers of PsA in cutaneous psoriasis patients.Methods:KLKs were measured by ELISAs in synovial fluids of three PsA patients and three control early osteoarthritis (OA) patients, as well as in a cohort of 152 serum samples collected from age- and sex-matched PsC patients, with (n=76) or without PsA (n=76). KLK expression in psoriatic plaques was examined by immunohistochemistry. Univariate and multivariate logistic regression analyses were conducted to analyze the association between serum KLK levels and disease class (PsC, PsA). Serum KLKs that associated with PsA were correlated with clinical parameters of skin and joint activity.Results:Among the seven KLKs tested, KLK6 and KLK8 were elevated in both PsA synovial fluids and psoriatic plaques, but only serum KLK8 levels were associated with psoriatic disease (odds ratio=2.56, p=0.03). Although significantly elevated in PsC and PsA sera compared to healthy controls, KLK8 did not discriminate PsA from PsC patients. KLK8 correlated positively with the psoriasis area and severity index (PASI) (r=0.43, p=0.001) independent of age, sex and psoriasis duration (β=1.153, p=0.0003) and exhibited no correlations with tender or swollen joint counts.Conclusions:Increased KLK8 serum level in PsA patients reflects disease activity in the skin but not in the joints. Serum KLK levels are not useful for screening psoriasis patients for PsA.Keywords
This publication has 30 references indexed in Scilit:
- Kallikrein-related Peptidase-8 (KLK8) Is an Active Serine Protease in Human Epidermis and Sweat and Is Involved in a Skin Barrier Proteolytic CascadeOnline Journal of Public Health Informatics, 2011
- Current status and new developments in the treatment of psoriasis and psoriatic arthritis with biological agentsBritish Journal of Pharmacology, 2010
- Kallikrein 5 induces atopic dermatitis–like lesions through PAR2-mediated thymic stromal lymphopoietin expression in Netherton syndromeThe Journal of Experimental Medicine, 2009
- The prevalence of previously diagnosed and undiagnosed psoriasis in US adults: Results from NHANES 2003-2004Journal of the American Academy of Dermatology, 2009
- New insights into the pathogenesis and genetics of psoriatic arthritisNature Clinical Practice Rheumatology, 2009
- Human tissue kallikreins as promiscuous modulators of homeostatic skin barrier functionsBiological Chemistry, 2008
- Aberrant human tissue kallikrein levels in the stratum corneum and serum of patients with psoriasis: dependence on phenotype, severity and therapyBritish Journal of Dermatology, 2007
- Quantification of Human Tissue Kallikreins in the Stratum Corneum: Dependence on Age and GenderJournal of Investigative Dermatology, 2005
- Increased matrix metalloproteinase-3 serum levels in rheumatic diseases: relationship with synovitis and steroid treatmentAnnals Of The Rheumatic Diseases, 2002
- Development of criteria for the classification and reporting of osteoarthritis: Classification of osteoarthritis of the kneeArthritis & Rheumatism, 1986