Parkinsonism in patients with a history of amphetamine exposure
- 30 January 2010
- journal article
- research article
- Published by Wiley in Movement Disorders
- Vol. 25 (2), 228-231
- https://doi.org/10.1002/mds.22915
Abstract
We recently found a higher rate of prolonged amphetamine exposure in patients diagnosed with Parkinson's disease (PD) than in spouse/caregiver controls. Since distinguishing features have been described in some patients with parkinsonism due to environment exposures (e.g., manganese), we sought to compare the clinical features of patients with PD with prolonged amphetamine exposure with unexposed patients with PD. Prolonged exposure was defined as a minimum of twice a week for ≥3 months, or weekly use ≥1 year. We reviewed the clinical records of patients with PD who had participated in a telephone survey of drug and environmental exposures and compared the clinical features of patients with a history of prolonged amphetamine exposure to patients who had no such exposure. Records were available for 16 of 17 (94%) patients with prior amphetamine exposure and 127 of 137 (92%) of those unexposed. Age at diagnosis was younger in the amphetamine‐exposed group (49.8 ± 8.2 years vs. 53.1 ± 7.4 years; P < 0.05), but other features, including presenting symptoms, initial and later treatments, development of motor fluctuations, and MRI findings were similar between these groups. Because we did not detect clinical features that differentiate parkinsonism in patients with prolonged amphetamine exposure, research to determine whether amphetamine exposure is a risk factor for parkinsonism will require detailed histories of medication and recreational drug use. © 2009 Movement Disorder SocietyFunding Information
- UCSF Department of Neurology
- Genzyme
- University of California
- Doris Duke Charitable Foundation
- San Francisco VA PADREC
- NIH
This publication has 15 references indexed in Scilit:
- Update in the epidemiology of Parkinson's diseaseCurrent Opinion in Neurology, 2008
- Neurologic Spectrum of Chronic Liver Failure and Basal Ganglia T1 Hyperintensity on Magnetic Resonance ImagingArchives of Neurology, 2005
- Amphetamine Treatment Similar to That Used in the Treatment of Adult Attention-Deficit/Hyperactivity Disorder Damages Dopaminergic Nerve Endings in the Striatum of Adult Nonhuman PrimatesThe Journal of pharmacology and experimental therapeutics, 2005
- Neurologic manifestations in welders with pallidal MRI T1 hyperintensityNeurology, 2005
- Why is parkinsonism not a feature of human methamphetamine users?Brain, 2004
- Methamphetamine neurotoxicity: necrotic and apoptotic mechanisms and relevance to human abuse and treatmentBrain Research Reviews, 2001
- Diagnostic Criteria for Parkinson DiseaseArchives of Neurology, 1999
- Reduced Striatal Dopamine Transporter Density in Abstinent Methamphetamine and Methcathinone Users: Evidence from Positron Emission Tomography Studies with [11C]WIN-35,428Journal of Neuroscience, 1998
- Striatal dopamine nerve terminal markers in human, chronic methamphetamine usersNature Medicine, 1996
- Aging Produces a Specific Pattern of Striatal Dopamine Loss: Implications for the Etiology of Idiopathic Parkinson's DiseaseJournal of Neurochemistry, 1992