Body mass index and risk of stroke among Chinese men and women
- 1 January 2010
- journal article
- research article
- Published by Wiley in Annals of Neurology
- Vol. 67 (1), 11-20
- https://doi.org/10.1002/ana.21950
Abstract
Objective The relationship between body mass index (BMI) and stroke incidence and mortality remains controversial, particularly in Asian populations. Methods We conducted a prospective cohort study in a nationally representative sample of 169,871 Chinese men and women age 40 years or older. Data on body weight was obtained at baseline examination in 1991 using a standard protocol. Follow‐up evaluation was conducted in 1999 to 2000, with a response rate of 93.4%. Results After excluding those participants with missing body weight or height values, 154,736 adults were included in the analysis. During a mean follow‐up of 8.3 years, 7,489 strokes occurred (3,924 fatal). After adjustment for age, gender, physical inactivity, urbanization, geographic variation, cigarette smoking, diabetes, and education, compared with participants of normal weight (BMI 18.5–24.9), relative hazard (95% confidence interval) of incident stroke was 0.86 (0.80–0.93) for participants who were underweight (BMI < 18.5), 1.43 (1.36–1.52) for those who were overweight (BMI 25–29.9), and 1.72 (1.55–1.91) for those who were obese (BMI ≥ 30). The corresponding relative hazards were 0.76 (0.66–0.86), 1.60 (1.48–1.72), and 1.89 (1.66–2.16) for ischemic stroke and 1.00 (0.89–1.13), 1.18 (1.06–1.31), and 1.54 (1.27–1.87) for hemorrhagic stroke. For stroke mortality, the corresponding relative hazards were 0.94 (0.86–1.03), 1.15 (1.05–1.25), and 1.47 (1.26–1.72). Linear trends were significant for all outcomes (p < 0.0001). Interpretation These results suggest that elevated BMI increases the risk of both ischemic and hemorrhagic stroke incidence, and stroke mortality in Chinese adults. ANN NEUROL 2010;67:11–20Keywords
This publication has 32 references indexed in Scilit:
- Body Mass Index, Blood Pressure, and Mortality From StrokeStroke, 2008
- Long-Term Risk Factors for StrokeStroke, 2006
- Body Mass Index and Mortality From Cardiovascular Disease Among Japanese Men and WomenStroke, 2005
- Stroke Incidence and Survival Among Middle-Aged AdultsStroke, 1999
- Body mass index and thromboembolic stroke in nonsmoking men in older middle age. The Honolulu Heart Program.Stroke, 1994
- Risk factors of stroke incidence and mortality. A 12-year follow-up of the Oslo Study.Stroke, 1993
- Risk factors for stroke in middle-aged men in Göteborg, Sweden.Stroke, 1990
- Serum cholesterol and hemorrhagic stroke in the Honolulu Heart Program.Stroke, 1989
- Serum Cholesterol Levels and Six-Year Mortality from Stroke in 350,977 Men Screened for the Multiple Risk Factor Intervention TrialThe New England Journal of Medicine, 1989
- Obesity as an independent risk factor for cardiovascular disease: a 26-year follow-up of participants in the Framingham Heart Study.Circulation, 1983