Dental pulp stem cells: function, isolation and applications in regenerative medicine
Top Cited Papers
Open Access
- 21 May 2014
- journal article
- review article
- Published by Hindawi Limited in Journal of Tissue Engineering and Regenerative Medicine
- Vol. 9 (11), 1205-1216
- https://doi.org/10.1002/term.1899
Abstract
Dental pulp stem cells (DPSCs) are a promising source of cells for numerous and varied regenerative medicine applications. Their natural function in the production of odontoblasts to create reparative dentin support applications in dentistry in the regeneration of tooth structures. However, they are also being investigated for the repair of tissues outside of the tooth. The ease of isolation of DPSCs from discarded or removed teeth offers a promising source of autologous cells, and their similarities with bone marrow stromal cells (BMSCs) suggest applications in musculoskeletal regenerative medicine. DPSCs are derived from the neural crest and, therefore, have a different developmental origin to BMSCs. These differences from BMSCs in origin and phenotype are being exploited in neurological and other applications. This review briefly highlights the source and functions of DPSCs and then focuses on in vivo applications across the breadth of regenerative medicine. © 2014 The Authors. Journal of Tissue Engineering and Regenerative Medicine published by John Wiley & Sons, Ltd.Keywords
Funding Information
- European Research Council under the European Community's Seventh Framework Programme (FP7/2007-2013/ERC)
This publication has 122 references indexed in Scilit:
- Biomimetic Approach to Perforation Repair Using Dental Pulp Stem Cells and Dentin Matrix Protein 1Journal of Endodontics, 2011
- The effect of scaffold architecture on odontogenic differentiation of human dental pulp stem cellsBiomaterials, 2011
- Stem cell-based biological tooth repair and regenerationTrends in Cell Biology, 2010
- Induction of Pluripotent Stem Cells from Human Third Molar Mesenchymal Stromal Cells*Published by Elsevier BV ,2010
- Effects of Cryopreservation of Intact Teeth on the Isolated Dental Pulp Stem CellsJournal of Endodontics, 2010
- Stem/Progenitor Cell–Mediated De Novo Regeneration of Dental Pulp with Newly Deposited Continuous Layer of Dentin in an In Vivo ModelTissue Engineering, Part A, 2010
- Optimized cryopreservation method for human dental pulp-derived stem cells and their tissues of origin for banking and clinical useCryobiology, 2009
- Fully functional bioengineered tooth replacement as an organ replacement therapyProceedings of the National Academy of Sciences, 2009
- In Vivo Generation of Dental Pulp-like Tissue by Using Dental Pulp Stem Cells, a Collagen Scaffold, and Dentin Matrix Protein 1 after Subcutaneous Transplantation in MiceJournal of Endodontics, 2008
- Making a tooth: growth factors, transcription factors, and stem cellsCell Research, 2005