THE RELATIVE IMPORTANCE OF BLOOD MONOCYTES AND FIXED MACROPHAGES TO THE EXPRESSION OF CELL-MEDIATED IMMUNITY TO INFECTION
Open Access
- 1 September 1970
- journal article
- Published by Rockefeller University Press in The Journal of Experimental Medicine
- Vol. 132 (3), 521-534
- https://doi.org/10.1084/jem.132.3.521
Abstract
Infection in mice with Listeria monocytogenes results in a substantial accumulation of migrant macrophages in the liver. The immigrant cells populate both the infective foci and intervening sinusoids. They have the labeling characteristics of blood monocytes, and their appearance in infective foci in the liver corresponds to the expression of a high level of antimicrobial immunity in this organ. The infected liver acquires additional new macrophages by Kupffer-cell division. The proliferation of these cells, however, is not essential for the expression of immunity in the liver. The results indicate that the macrophages which express immunity to a primary infection with L. monocytogenes are those derived from circulating monocytes. Most of these cells are quickly lost once the parasite is eliminated from the tissues.Keywords
This publication has 10 references indexed in Scilit:
- THE MITOTIC POTENTIAL OF FIXED PHAGOCYTES IN THE LIVER AS REVEALED DURING THE DEVELOPMENT OF CELLULAR IMMUNITYThe Journal of Experimental Medicine, 1969
- CELLULAR KINETICS ASSOCIATED WITH THE DEVELOPMENT OF ACQUIRED CELLULAR RESISTANCEThe Journal of Experimental Medicine, 1969
- THE INFLUENCE OF IMMUNOLOGICALLY COMMITTED LYMPHOID CELLS ON MACROPHAGE ACTIVITY IN VIVOThe Journal of Experimental Medicine, 1969
- THE ORIGIN AND KINETICS OF MONONUCLEAR PHAGOCYTESThe Journal of Experimental Medicine, 1968
- Pathways in the development of liver macrophages: alternative precursors contained in populations of lymphocytes and bone-marrow cellsProceedings of the Royal Society of London. B. Biological Sciences, 1968
- Hydroxyethyl Methacrylate Combined with Polyethylene Glycol 400 and Water; an Embedding Medium for Routine 1–2 Micron SectioningStain Technology, 1967
- THE ORIGIN OF MACROPHAGES FROM BONE MARROW IN THE RAT.1965
- THE IMMUNOLOGICAL BASIS OF ACQUIRED CELLULAR RESISTANCEThe Journal of Experimental Medicine, 1964
- HIGH-RESOLUTION AUTORADIOGRAPHYThe Journal of cell biology, 1962
- CELLULAR RESISTANCE TO INFECTIONThe Journal of Experimental Medicine, 1962