The multilayered complexity of ceRNA crosstalk and competition
Top Cited Papers
- 15 January 2014
- journal article
- review article
- Published by Springer Science and Business Media LLC in Nature
- Vol. 505 (7483), 344-352
- https://doi.org/10.1038/nature12986
Abstract
Recent reports have described an intricate interplay among diverse RNA species, including protein-coding messenger RNAs and non-coding RNAs such as long non-coding RNAs, pseudogenes and circular RNAs. These RNA transcripts act as competing endogenous RNAs (ceRNAs) or natural microRNA sponges — they communicate with and co-regulate each other by competing for binding to shared microRNAs, a family of small non-coding RNAs that are important post-transcriptional regulators of gene expression. Understanding this novel RNA crosstalk will lead to significant insight into gene regulatory networks and have implications in human development and disease.Keywords
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