Functional strain as a determinant for bone remodeling
- 1 March 1984
- journal article
- Published by Springer Science and Business Media LLC in Calcified Tissue International
- Vol. 36 (S1), S56-S61
- https://doi.org/10.1007/bf02406134
Abstract
Mechanical function has always been acknowledged to have a significant, continuing but hitherto unquantified influence on bone remodeling. The structural objective of this relationship is presumably to ensure that, at each location throughout the skeleton, there is sufficient bone tissue, appropriately placed, to withstand functional load-bearing without damage. The architectural modifications necessary to achieve and maintain this structural competence are made by the coordinated remodeling activity of populations of osteoblasts and osteoclasts. The specific structure-function objectives at each location remain undefined, as are the mechanisms by which tissue loading is transduced into cellular control. The remodeling responses following a variety of experimental alterations in bones' strain environment are presented. Their significance to the process of remodeling control is discussed, and a scheme for the interaction of mechanical and hormonal influences proposed.Keywords
This publication has 20 references indexed in Scilit:
- Static vs dynamic loads as an influence on bone remodellingJournal of Biomechanics, 1984
- Bone Cell Differentiation and Growth FactorsScience, 1983
- Physical Exercise as Prophylaxis against Involutional Vertebral Bone Loss: A Controlled TrialClinical Science, 1983
- Vertebral Bone Loss: An Unheeded Side Effect of Therapeutic Bed RestClinical Science, 1983
- Extracts of Human Cancellous Bone Stimulate DNA Synthesis in Osteoprogenitor Cells from Fetal RatsPublished by Ovid Technologies (Wolters Kluwer Health) ,1983
- Mechanically adaptive bone remodellingJournal of Biomechanics, 1982
- The influence of strain rate on adaptive bone remodellingJournal of Biomechanics, 1982
- Nuclear size as a cell‐kinetic marker for osteoblast differentiationJournal of Anatomy, 1982
- Extracts of bone contain a potent regulator of bone formationBiochimica et Biophysica Acta (BBA) - General Subjects, 1982
- Effect of prolonged bed rest on bone mineralMetabolism, 1970