Sialic acid is an essential moiety of mucin as a hydroxyl radical scavenger
- 30 April 2007
- journal article
- Published by Wiley in FEBS Letters
- Vol. 581 (13), 2473-2477
- https://doi.org/10.1016/j.febslet.2007.04.062
Abstract
In this work, we examined the antioxidant role of mucin, a typical sialic acid containing high-molecular weight glycoprotein. The function of mucin as a hydroxyl radical (.OH) scavenger was characterized using bovine submaxillary gland mucin (BSM). Non-treated BSM effectively protected DNA from the attack of .OH; however, desialylated BSM lost this potential. Moreover, we estimated the scavenging effects of BSM against .OH generated by UV irradiation of hydrogen peroxide using ESR analysis. Our results indicate that BSM has .OH scavenging ability the and sialic acid in mucin is an essential moiety to scavenge .OH.Keywords
This publication has 22 references indexed in Scilit:
- Modification of oligosaccharides by reactive oxygen species decreases sialyl lewis x-mediated cell adhesionGlycobiology, 2005
- Novel biological function of sialic acid (N‐acetylneuraminic acid) as a hydrogen peroxide scavengerFEBS Letters, 2004
- Human MUC1 Carcinoma Antigen Regulates Intracellular Oxidant Levels and the Apoptotic Response to Oxidative StressPublished by Elsevier BV ,2003
- Biphasic Regulation of Leukocyte Superoxide Generation by Nitric Oxide and PeroxynitritePublished by Elsevier BV ,2000
- Occurrence of Oxidatively Modified Proteins: An Early Event in Experimental Acute PancreatitisFree Radical Biology & Medicine, 1998
- Salivary mucins in oral mucosal defenseGeneral Pharmacology: The Vascular System, 1996
- OXIDANTS, ANTIOXIDANTS, AND RESPIRATORY-TRACT LINING FLUIDSEnvironmental Health Perspectives, 1994
- ANTIOXIDANT PROTECTION: A FUNCTION OF TRACHEOBRONCHIAL AND GASTROINTESTINAL MUCUSThe Lancet, 1984
- Formation of a thiobarbituric‐acid‐reactive substance from deoxyribose in the presence of iron saltsFEBS Letters, 1981
- A compilation of specific bimolecular rate constants for the reactions of hydrated electrons, hydrogen atoms and hydroxyl radicals with inorganic and organic compounds in aqueous solutionThe International Journal of Applied Radiation and Isotopes, 1967