Body Size in Early Life and Adult Levels of Insulin-like Growth Factor 1 and Insulin-like Growth Factor Binding Protein 3
Open Access
- 9 August 2011
- journal article
- research article
- Published by Oxford University Press (OUP) in American Journal of Epidemiology
- Vol. 174 (6), 642-651
- https://doi.org/10.1093/aje/kwr123
Abstract
Body size in early life has been associated with breast cancer risk. This may be partly mediated through the insulin-like growth factor (IGF) pathway. The authors assessed whether birth weight, body fatness at ages 5 and 10 years, and body mass index (BMI; weight (kg)/height (m)2) at age 18 years were associated with plasma concentrations of insulin-like growth factor 1 (IGF-1) and insulin-like growth factor binding protein 3 in 6,520 women aged 32–70 years at blood draw from the Nurses’ Health Study (1990–2006) and Nurses’ Health Study II (1997–2005). Birth weight, body fatness in childhood, and BMI at age 18 years were inversely associated with adult IGF-1 levels. For example, IGF-1 levels were 11.9% lower in women who reported being heaviest at age 10 years than in those who were leanest at age 10 (P-trend < 0.0001). Further, women who reported their birth weight as ≥10 pounds (≥4.5 kg) (vs. P-trend = 0.002). Women whose BMI at age 18 years was ≥30 (vs. P-trend < 0.0001). Similar inverse associations were observed for insulin-like growth factor binding protein 3. These observations did not vary by adult BMI or menopausal status at blood draw. These findings suggest that altered IGF-1 levels in adulthood may be a mechanism through which early-life body size influences subsequent breast cancer risk.Keywords
This publication has 64 references indexed in Scilit:
- Plasma insulin-like growth factor 1 is positively associated with low-grade prostate cancer in the Health Professionals Follow-up Study 1993-2004International Journal of Cancer, 2010
- Insulin-like growth factor 1 (IGF1), IGF binding protein 3 (IGFBP3), and breast cancer risk: pooled individual data analysis of 17 prospective studiesThe Lancet Oncology, 2010
- Insulin-like growth factors and risk of kidney cancer in menBritish Journal of Cancer, 2010
- Body Fatness at Young Ages and Risk of Breast Cancer Throughout LifeAmerican Journal of Epidemiology, 2010
- Body size, adult BMI gain and endometrial cancer risk: the multiethnic cohortInternational Journal of Cancer, 2009
- Genetic variation and circulating levels of IGF‐I and IGFBP‐3 in relation to risk of proliferative benign breast diseaseInternational Journal of Cancer, 2009
- Body size in early life and risk of epithelial ovarian cancer: results from the Nurses' Health StudiesBritish Journal of Cancer, 2008
- Energy balance, early life body size, and plasma prolactin levels in postmenopausal womenCancer Causes & Control, 2008
- Longitudinal study on birthweight and the incidence of endometrial cancerBritish Journal of Cancer, 2008
- Birth weight in relation to endometrial and breast cancer risks in Swedish womenBritish Journal of Cancer, 2006