Regioselectivity in the ring opening of non-activated aziridines
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- 6 September 2011
- journal article
- review article
- Published by Royal Society of Chemistry (RSC) in Chemical Society Reviews
- Vol. 41 (2), 643-665
- https://doi.org/10.1039/c1cs15140a
Abstract
In this critical review, the ring opening of non-activated 2-substituted aziridinesvia intermediate aziridinium salts will be dealt with. Emphasis will be put on the relationship between the observed regioselectivity and inherent structural features such as the nature of the C2 aziridine substituent and the nature of the electrophile and the nucleophile. This overview should allow chemists to gain insight into the factors governing the regioselectivity in aziridinium ring openings (81 references).Keywords
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