Nutritional rickets around the world: causes and future directions
- 1 March 2006
- journal article
- review article
- Published by Informa UK Limited in Paediatrics and International Child Health
- Vol. 26 (1), 1-16
- https://doi.org/10.1179/146532806x90556
Abstract
Nutritional rickets has been described from at least 59 countries in the last 20 years. Its spectrum of causes differs in different regions of the world. We conducted a systematic review of articles on nutritional rickets from various geographical regions published in the last 20 years. We extracted information about the prevalence and causes of rickets. Calcium deficiency is the major cause of rickets in Africa and some parts of tropical Asia, but is being recognised increasingly in other parts of the world. A resurgence of vitamin D deficiency has been observed in North America and Europe. Vitamin D-deficiency rickets usually presents in the 1st 18 months of life, whereas calcium deficiency typically presents after weaning and often after the 2nd year. Few studies of rickets in developing countries report values of 25(OH)D to permit distinguishing vitamin D from calcium deficiency. Rickets exists along a spectrum ranging from isolated vitamin D deficiency to isolated calcium deficiency. Along the spectrum, it is likely that relative deficiencies of calcium and vitamin D interact with genetic and/or environmental factors to stimulate the development of rickets. Vitamin D supplementation alone might not prevent or treat rickets in populations with limited calcium intake.Keywords
This publication has 100 references indexed in Scilit:
- Higher Prevalence of Vitamin D Deficiency in Mothers of Rachitic Than Nonrachitic ChildrenThe Journal of Pediatrics, 2005
- Seasonal Deficiency of Vitamin D in Children: A Potential Target for Osteoporosis-Preventing Strategies?Journal of Bone and Mineral Research, 1998
- Etiology of rickets in Nigerian childrenThe Journal of Pediatrics, 1996
- Etiology of nutritional rickets: Geographic variationsThe Journal of Pediatrics, 1996
- Single-day therapy for nutritional vitamin D-deficiency rickets: A preferred methodThe Journal of Pediatrics, 1994
- Calcium-deficiency rickets in a four-year-old boywith milk allergyThe Journal of Pediatrics, 1993
- Serum Concentrations of Vitamin D Metabolites in Rachitic Libyan ChildrenJournal of Pediatric Gastroenterology and Nutrition, 1989
- A new mechanism for induced vitamin D deficiency in calcium deprivationNature, 1987
- Rickets Due to Calcium DeficiencyNew England Journal of Medicine, 1977
- Vitamin D deficiency rickets in GreeceThe Journal of Pediatrics, 1968