The Vχ genes of the L regions and the repertoire of Vχ gene sequences in the human germ line
- 1 November 1993
- journal article
- research article
- Published by Wiley in European Journal of Immunology
- Vol. 23 (11), 2868-2875
- https://doi.org/10.1002/eji.1830231121
Abstract
Only 14 of the 25 Vχ genes and pseudogenes had been found before as parts of the L regions. The cloning and linking described in the accompanying report allowed us now to assign to Lp or Ld some Vχ genes which had been found before on scattered clones. In addition the sequences of several still unknown genes are reported here, thus completing the publication of the Vχ genes of the x locus as far as they are potentially functional or have only one or two 1-bp defects. Of the Vχ genes of the K locus, 32 are potentially functional, 16 have minor defects, 3 have both potentially functional and slightly defective alleles and 25 are pseudogenes which amounts to a repertoire of 76 Vχ-related gene sequences. The Vχ genes of the L regions are, within the subgroups, particularly similar to each other, which is in part due to common evolutionary origins and in part caused by gene conversion-like events. One donor-acceptor pair could be clearly identified, since converted and not-converted alleles of the acceptor gene were found. In other cases the duplicates of the converted genes served as non-converted controls.Keywords
This publication has 28 references indexed in Scilit:
- The human immunoglobulin χ locus. Characterization of the partially duplicated L regionsEuropean Journal of Immunology, 1993
- The CD8α Locus Is Located on the Telomere Side of the Immunoglobulin κ Locus at a Distance of 2 MbGenomics, 1993
- Of Orphons and UHOs. Delimitation of the Germline Repertoire of Human Immunoglobulin ϰ GenesBiological Chemistry Hoppe-Seyler, 1992
- The Vϰ gene repertoire in the human germ lineEuropean Journal of Immunology, 1990
- The Jκ proximal region of the human K locus contains three uncommon Vκ genes which are arranged in opposite transcriptional polaritiesMolecular Immunology, 1988
- The human VK locusJournal of Molecular Biology, 1988
- The human Vκ locus: Characterization of extended immunoglobulin gene regions by cosmid cloningJournal of Molecular Biology, 1987
- A large section of the gene locus encoding human immunoglobulin variable regions of the Kappa type is duplicatedJournal of Molecular Biology, 1985
- Organization and evolution of a gene cluster for human immunoglobulin variable regions of the kappa typeJournal of Molecular Biology, 1984
- Human immunoglobulin variable region genes—DNA sequences of two Vκ genes and a pseudogeneNature, 1980