Follow-up of Children Exposed In Utero to 17 α-Hydroxyprogesterone Caproate Compared With Placebo
- 1 October 2007
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in Obstetrics & Gynecology
- Vol. 110 (4), 865-872
- https://doi.org/10.1097/01.aog.0000281348.51499.bc
Abstract
To assess whether there are evident adverse effects of 17 alpha-hydroxyprogesterone caproate after in utero exposure. This study evaluated surviving children of mothers who participated in a multicenter placebo-controlled trial of weekly intramuscular 17 alpha-hydroxyprogesterone caproate, with a 2:1 allocation to 17 alpha-hydroxyprogesterone caproate and placebo, respectively. The guardian was interviewed about the child's general health. Children underwent a physical examination and developmental screen with the Ages and Stages Questionnaire. Gender-specific roles were assessed with the Preschool Activities Inventory. Of 348 eligible surviving children, 278 (80%) were available for evaluation (194 in the 17 alpha-hydroxyprogesterone caproate group and 84 in the placebo group). The mean age at follow-up was 48 months. No significant differences were seen in health status or physical examination, including genital anomalies, between 17 alpha-hydroxyprogesterone caproate and placebo children. Scores for gender-specific roles (Preschool Activities Inventory) were within the normal range and similar between 17 alpha-hydroxyprogesterone caproate and placebo groups. 17 alpha-hydroxyprogesterone caproate seems to be safe for the fetus when administered in the second and third trimesters.Keywords
This publication has 16 references indexed in Scilit:
- The Pre-School Activities Inventory: A standardized assessment of gender role in children.Psychological Assessment, 1993
- Evaluation of the teratogenic potential of Delalutin (17α‐hydroxyprogesterone caproate) in miceTeratology, 1983
- Prospective study of suspected associations between certain drugs administered during early pregnancy and congenital malformationsTeratology, 1983
- Prenatal ‘female hormone’ administration and psychosexual development in human malesPsychoneuroendocrinology, 1980
- Prenatal exposure of human foetuses to synthetic progestin and oestrogen affects personalityNature, 1977
- Prenatal Progesterone and Educational AttainmentsThe British Journal of Psychiatry, 1976
- Ante-natal Progesterone and IntelligenceThe British Journal of Psychiatry, 1968
- Teratology in theMacaca mulattaTeratology, 1968
- INDUCED GENITAL ANOMALIES*Annals of the New York Academy of Sciences, 1967
- SOME BIOLOGICAL ACTIVITIES OF CERTAIN PROGESTOGENS: I. 17?-HYDROXYPROGESTERONE 17-n-CAPROATEAnnals of the New York Academy of Sciences, 1958