Private aspects of heterologous immunity
Open Access
- 7 March 2005
- journal article
- review article
- Published by Rockefeller University Press in The Journal of Experimental Medicine
- Vol. 201 (5), 667-670
- https://doi.org/10.1084/jem.20050220
Abstract
Clinical manifestations of viral infections are highly variable, both in type and severity, among individual patients. Differences in host genetics and in dose and route of infection contribute to this variability but do not fully explain it. New studies now show that each subject's history of past infections individualizes the memory T cell pool. Private T cell receptor specificities of these preexisting memory T cell populations influence both disease severity and outcome of subsequent, unrelated virus infections.This publication has 29 references indexed in Scilit:
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