Cadherin-mediated Intercellular Adhesion and Signaling Cascades Involving Small GTPases
Open Access
- 12 August 2009
- journal article
- review article
- Published by Cold Spring Harbor Laboratory in Cold Spring Harbor Perspectives in Biology
- Vol. 1 (3), a003020
- https://doi.org/10.1101/cshperspect.a003020
Abstract
Epithelia form physical barriers that separate the internal milieu of the body from its external environment. The biogenesis of functional epithelia requires the precise coordination of many cellular processes. One of the key events in epithelial biogenesis is the establishment of cadherin-dependent cell–cell contacts, which initiate morphological changes and the formation of other adhesive structures. Cadherin-mediated adhesions generate intracellular signals that control cytoskeletal reorganization, polarity, and vesicle trafficking. Among such signaling pathways, those involving small GTPases play critical roles in epithelial biogenesis. Assembly of E-cadherin activates several small GTPases and, in turn, the activated small GTPases control the effects of E-cadherin-mediated adhesions on epithelial biogenesis. Here, we focus on small GTPase signaling at E-cadherin-mediated epithelial junctions.Keywords
This publication has 96 references indexed in Scilit:
- Identification of the stef Gene That Encodes a Novel Guanine Nucleotide Exchange Factor Specific for Rac1Published by Elsevier BV ,1999
- Interaction of S-SCAM with Neural Plakophilin-RelatedArmadillo-Repeat Protein/δ-CateninBiochemical and Biophysical Research Communications, 1999
- A Novel PDZ Domain Containing Guanine Nucleotide Exchange Factor Links Heterotrimeric G Proteins to RhoPublished by Elsevier BV ,1999
- Regulation of Cadherin Function by Rho and Rac: Modulation by Junction Maturation and Cellular ContextMolecular Biology of the Cell, 1999
- Cytomechanics of cadherin-mediated cell—cell adhesionCurrent Opinion in Cell Biology, 1998
- Role of IQGAP1, a Target of the Small GTPases Cdc42 and Rac1, in Regulation of E-Cadherin- Mediated Cell-Cell AdhesionScience, 1998
- Effects of Regulated Expression of Mutant RhoA and Rac1 Small GTPases on the Development of Epithelial (MDCK) Cell PolarityThe Journal of cell biology, 1998
- Activation of Rac and Cdc42 by Integrins Mediates Cell SpreadingMolecular Biology of the Cell, 1998
- Regulation of Cell–Cell Adhesion by Rac and Rho Small G Proteins in MDCK CellsThe Journal of cell biology, 1997
- Dissociation of LPA-induced cytoskeletal contraction from stress fiber formation by differential localization of RhoAJournal of Cell Science, 1997