Real-life glycaemic profiles in non-diabetic individuals with low fasting glucose and normal HbA1c: the A1C-Derived Average Glucose (ADAG) study
Open Access
- 16 April 2010
- journal article
- research article
- Published by Springer Science and Business Media LLC in Diabetologia
- Vol. 53 (8), 1608-1611
- https://doi.org/10.1007/s00125-010-1741-9
Abstract
Aims/hypothesis Real-life glycaemic profiles of healthy individuals are poorly studied. Our aim was to analyse to what extent individuals without diabetes exceed OGTT thresholds for impaired glucose tolerance (IGT) and diabetes. Methods In the A1C-Derived Average Glucose (ADAG) study, 80 participants without diabetes completed an intensive glucose monitoring period of 12 weeks. From these data, we calculated the average 24 h glucose exposure as time spent above different plasma glucose thresholds. We also derived indices of postprandial glucose levels, glucose variability and HbA1c. Results We found that 93% of participants reached glucose concentrations above the IGT threshold of 7.8 mmol/l and spent a median of 26 min/day above this level during continuous glucose monitoring. Eight individuals (10%) spent more than 2 h in the IGT range. They had higher HbA1c, fasting plasma glucose (FPG), age and BMI than those who did not. Seven participants (9%) reached glucose concentrations above 11.1 mmol/l during monitoring. Conclusions/interpretation Even though the non-diabetic individuals monitored in the ADAG study were selected on the basis of a very low level of baseline FPG, 10% of these spent a considerable amount of time at glucose levels considered to be ‘prediabetic’ or indicating IGT. This highlights the fact that exposure to moderately elevated glucose levels remains under-appreciated when individuals are classified on the basis of isolated glucose measurements.Keywords
This publication has 8 references indexed in Scilit:
- International Expert Committee Report on the Role of the A1C Assay in the Diagnosis of DiabetesDiabetes Care, 2009
- Continuous Glucose Monitoring System in Free-Living Healthy Subjects: Results from a Pilot StudyDiabetes Technology & Therapeutics, 2009
- Translating the A1C Assay Into Estimated Average Glucose ValuesDiabetes Care, 2008
- Characterizing Glucose Exposure for Individuals with Normal Glucose Tolerance Using Continuous Glucose Monitoring and Ambulatory Glucose Profile AnalysisDiabetes Technology & Therapeutics, 2008
- Management of Hyperglycemia in Type 2 Diabetes: A Consensus Algorithm for the Initiation and Adjustment of TherapyDiabetes Care, 2008
- Contributions of β-Cell Dysfunction and Insulin Resistance to the Pathogenesis of Impaired Glucose Tolerance and Impaired Fasting GlucoseDiabetes Care, 2006
- Contributions of -Cell Dysfunction and Insulin Resistance to the Pathogenesis of Impaired Glucose Tolerance and Impaired Fasting GlucoseDiabetes Care, 2006
- Follow-up Report on the Diagnosis of Diabetes MellitusDiabetes Care, 2003