Gastric cancer in sub-Saharan Africa
- 1 December 2001
- journal article
- review article
- Published by Ovid Technologies (Wolters Kluwer Health) in European Journal Of Cancer Prevention
- Vol. 10 (6), 479-482
- https://doi.org/10.1097/00008469-200112000-00001
Abstract
Gastric cancer has a variable but generally low prevalence in black populations of sub-Saharan Africa, despite a high prevalence of Helicobacter pylori (the ‘African enigma’). Evidence from Soweto indicates that the host response to H. pylori may be protective against a virulent organism and that, in most people, H. pylori does not lead to more serious sequelae. This suggests that there may be host protective/inhibitory factors present, which prevent the progression of H. pylori-induced chronic active gastritis to cancer.Keywords
This publication has 12 references indexed in Scilit:
- Helicobacter pylori gastritis in AfricaEuropean Journal of Gastroenterology & Hepatology, 2000
- Trends over time in Helicobacter pylori gastritis in KenyaEuropean Journal of Gastroenterology & Hepatology, 2000
- Concurrent enteric helminth infection modulates inflammation and gastric immune responses and reduces helicobacter-induced gastric atrophyNature Medicine, 2000
- Interleukin-1 polymorphisms associated with increased risk of gastric cancerNature, 2000
- Helicobacter pylori in Africa: Observations on an ‘enigma within an enigma’Journal of Gastroenterology and Hepatology, 1999
- A randomised, double blind, multicentre trial of octreotide in moderate to severe acute pancreatitisGut, 1999
- Helicobacter pylori: the African enigmaGut, 1998
- Prevalence of Helicobacter pylori Antibodies in Children in Bloemfontein, South AfricaJournal of Pediatric Gastroenterology and Nutrition, 1997
- South Africa's Health: Impressions of health in the new South Africa: a period of convalescenceBMJ, 1995
- Helicobacter pylori: the African enigma.Gut, 1992