One Hundred Years of Pleiotropy: A Retrospective
- 1 November 2010
- journal article
- review article
- Published by Oxford University Press (OUP) in Genetics
- Vol. 186 (3), 767-773
- https://doi.org/10.1534/genetics.110.122549
Abstract
Pleiotropy is defined as the phenomenon in which a single locus affects two or more distinct phenotypic traits. The term was formally introduced into the literature by the German geneticist Ludwig Plate in 1910, 100 years ago. Pleiotropy has had an important influence on the fields of physiological and medical genetics as well as on evolutionary biology. Different approaches to the study of pleiotropy have led to incongruence in the way that it is perceived and discussed among researchers in these fields. Furthermore, our understanding of the term has changed quite a bit since 1910, particularly in light of modern molecular data. This review traces the history of the term “pleiotropy” and reevaluates its current place in the field of genetics.Keywords
This publication has 62 references indexed in Scilit:
- ANTAGONISTIC COEVOLUTION OF TWO IMPRINTED LOCI WITH PLEIOTROPIC EFFECTSEvolution, 2010
- RNA editing: a driving force for adaptive evolution?BioEssays, 2009
- Genetic architecture of quantitative traits in mice, flies, and humansGenome Research, 2009
- What can genetic variation tell us about the evolution of senescence?Proceedings. Biological sciences, 2009
- Pleiotropic scaling of gene effects and the ‘cost of complexity’Nature, 2008
- Genetic variation in the cysteine biosynthesis pathway causes sensitivity to pharmacological compoundsProceedings of the National Academy of Sciences of the United States of America, 2007
- Toward a Molecular Understanding of PleiotropyGenetics, 2006
- Phenotypic Variation and Natural Selection at Catsup, a Pleiotropic Quantitative Trait Gene in DrosophilaCurrent Biology, 2006
- Wrestling with pleiotropy: Genomic and topological analysis of the yeast gene expression networkBioEssays, 2002
- An analysis of the “pleiotropic” effects of a new lethal mutation in the rat ( Mus norvegicus )Proceedings of the Royal Society of London. Series B - Biological Sciences, 1938