Cardiorespiratory Fitness Is an Independent Predictor of Hypertension Incidence among Initially Normotensive Healthy Women
Open Access
- 17 November 2005
- journal article
- research article
- Published by Oxford University Press (OUP) in American Journal of Epidemiology
- Vol. 163 (2), 142-150
- https://doi.org/10.1093/aje/kwj019
Abstract
The authors examined the association between cardiorespiratory fitness and incident hypertension in women who were normotensive and free of cardiovascular disease at baseline in the Aerobics Center Longitudinal Study (Dallas, Texas), 1970–1998. A total of 4,884 women performed a maximal treadmill exercise test and completed a follow-up health survey. During an average follow-up of 5 years, 157 incident cases of self-reported, physician-diagnosed hypertension were identified from the health surveys. The cumulative incidence of hypertension was 3.2%. Compared with the rates of low-fit women, crude hypertension rates were 60% and 79% lower among women in the moderate and high fitness categories, respectively (p < 0.001). After adjustment for several potential confounders, the odds ratios for hypertension were 1.0, 0.61 (95% confidence interval (CI): 0.30, 1.21), and 0.35 (95% CI: 0.17, 0.73) in low-, moderately, and highly fit women, respectively (ptrend < 0.01). Each 1-metabolic equivalent increment in treadmill performance was, on average, associated with a 19% (95% CI: 10, 27; p < 0.001) lower odds of incident hypertension. The pattern and strength of association between fitness and hypertension persisted in analyses stratified on body mass index, age, and the presence of prehypertension at baseline. An active lifestyle should be promoted for the primary prevention of hypertension in women.Keywords
This publication has 48 references indexed in Scilit:
- Blood Pressure and Risk of Secondary Cardiovascular Events in WomenCirculation, 2004
- Exercise and HypertensionMedicine & Science in Sports & Exercise, 2004
- Regular Exercise as an Effective Approach in Antihypertensive TherapyMedicine & Science in Sports & Exercise, 2004
- Age-specific relevance of usual blood pressure to vascular mortality: a meta-analysis of individual data for one million adults in 61 prospective studiesThe Lancet, 2002
- Antecedent Blood Pressure and Risk of Cardiovascular DiseaseCirculation, 2002
- Assessment of frequency of progression to hypertension in non-hypertensive participants in the Framingham Heart Study: a cohort studyThe Lancet, 2001
- Impact of High-Normal Blood Pressure on the Risk of Cardiovascular DiseaseThe New England Journal of Medicine, 2001
- Physical Activity and Incident Hypertension in Black and White Adults: The Atherosclerosis Risk in Communities StudyPreventive Medicine, 1999
- Blood Pressure, Systolic and Diastolic, and Cardiovascular RisksArchives of Internal Medicine, 1993
- PHYSICAL ACTIVITY AND INCIDENCE OF HYPERTENSION IN COLLEGE ALUMNIAmerican Journal of Epidemiology, 1983