Genomics, the cytoskeleton and motility
- 15 February 2001
- journal article
- Published by Springer Science and Business Media LLC in Nature
- Vol. 409 (6822), 842-843
- https://doi.org/10.1038/35057029
Abstract
The draft human genome sequence is an important step in cataloguing the molecular hardware that supports the processes of life. Here I look at what we have learned from the draft sequence about our cytoskeletal and motility systems. Most cytoskeletal and motility proteins were discovered previously by biochemical isolation, traditional cloning methods or random sequences of complementary DNAs. The ongoing challenges of assembling and annotating genes for motor proteins with long, fragmented coding sequences emphasize the importance of expert knowledge of related proteins and confirmatory evidence from cDNA sequences.This publication has 9 references indexed in Scilit:
- Sequencing solution: use volunteer annotators organized via InternetNature, 2000
- Actin-Related ProteinsAnnual Review of Cell and Developmental Biology, 1999
- Regulation of Actin Polymerization by Arp2/3 Complex and WASp/Scar ProteinsPublished by Elsevier BV ,1999
- Guidebook to the Cytoskeletal and Motor ProteinsPublished by Oxford University Press (OUP) ,1999
- The role of cytoskeletal proteins in cardiomyopathiesCurrent Opinion in Cell Biology, 1998
- FISH localization of human cytoplasmic actin genes ACTB to 7p22 and ACTG1 to 17q25 and characterization of related pseudogenesCytogenetic and Genome Research, 1996
- Actin-related protein nomenclature and classification.The Journal of cell biology, 1994
- Evolution of the functional human beta-actin gene and its multi-pseudogene family: conservation of noncoding regions and chromosomal dispersion of pseudogenes.Molecular and Cellular Biology, 1985
- Isolation and characterization of full-length cDNA clones for human alpha-, beta-, and gamma-actin mRNAs: skeletal but not cytoplasmic actins have an amino-terminal cysteine that is subsequently removed.Molecular and Cellular Biology, 1983