Electro-Acupuncture Reverses Nerve Growth Factor Abundance in Experimental Polycystic Ovaries in the Rat
- 1 January 2004
- journal article
- research article
- Published by S. Karger AG in Gynecologic and Obstetric Investigation
- Vol. 57 (2), 80-85
- https://doi.org/10.1159/000075382
Abstract
Polycystic ovary syndrome (PCOS) remains one of the most common causes of anovulation in women of reproductive age. There is some evidence that nerve growth factor (NGF) is involved in the pathogenesis of PCOS. Therefore, seeking the pathogenesis of PCOS is important for controlling fertility. In traditional Oriental Medicine, acupuncture has been used for the function of ovaries. The present study was designed to determine whether electro-acupuncture (EA) could affect experimentally induced polycystic ovary (PCO) in the rat. The two acupoints Sp-6 and E-128 were stimulated to test for efficacy in the protein expression of NGF. Polycystic ovaries were induced by a single injection of estradiol valerate (4 mg i.m.). During the experimental period of 8 weeks, some of the rats were treated with EA twice weekly; this group was compared with a vehicle-treated control group and an estradiol-injected group not subjected to EA. At day 60, the protein expression of NGF was examined by immunohistochemistry in the ovaries, the adrenal glands and some parts of the brain. The estradiol treatment induced a clear PCO appearance, and was associated with a robust increase in NGF expression in the ovaries, the adrenal glands and the brain. EA treatment partly reversed the NGF abundance, particularly in the ovaries, but not in the brain. Our data show that EA affects the NGF involvement in ovarian dysfunction.Keywords
This publication has 7 references indexed in Scilit:
- Strategies for the use of insulin-sensitizing drugs to treat infertility in women with polycystic ovary syndromeFertility and Sterility, 2002
- An Increased Intraovarian Synthesis of Nerve Growth Factor and Its Low Affinity Receptor Is a Principal Component of Steroid-Induced Polycystic Ovary in the RatEndocrinology, 2000
- Effects of electro‐acupuncture on anovulation in women with polycystic ovary syndromeActa Obstetricia et Gynecologica Scandinavica, 2000
- Modern use of clomiphene citrate in induction of ovulationHuman Reproduction Update, 1997
- A role for trkA nerve growth factor receptors in mammalian ovulationEndocrinology, 1996
- Ovarian steroidal response to gonadotropins and beta-adrenergic stimulation is enhanced in polycystic ovary syndrome: role of sympathetic innervationEndocrinology, 1993
- Activation of ovarian sympathetic nerves in polycystic ovary syndromeEndocrinology, 1993