Hantavirus pulmonary syndrome in Latin America
- 1 October 2004
- journal article
- review article
- Published by Ovid Technologies (Wolters Kluwer Health) in Current Opinion in Infectious Diseases
- Vol. 17 (5), 427-431
- https://doi.org/10.1097/00001432-200410000-00007
Abstract
Since the identification of hantavirus pulmonary syndrome in the United States in 1993, Latin America has been the region of the world where more hantaviruses have been identified, associated with human disease or not. This update shows the advances in the study of hantaviruses in several countries of the region and the problems that are still unresolved. Clinical findings in Chile have shown differences in the classical description of hantavirus pulmonary syndrome in the United States. Hemorrhage was observed in 64% of the cases and alteration in renal function in 48%. The classification of cases in mild, self-limited forms and severe forms has a prognostic value, with statistically significant differences between survivors and nonsurvivors. Epidemiological studies have shown noticeable differences in seroprevalence of antibodies against hantaviruses in humans, ranging from about 1% to more than 40% according to geographical and ethnical differences. Risk factors continue to be related to rural activities and peridomestic sites. Rodent studies have allowed the identification of putative reservoirs of hantaviruses in Uruguay, Brazil and Argentina and detected antibodies in several rodent species not previously reported in Paraguay and Panama. An Andes virus gene-based hantavirus pulmonary syndrome vaccine is currently under study. Progress in research on hantaviruses has been continuous but slow. The complex picture of the viruses, the rodent reservoirs and the clinical forms of the disease mean researchers are faced with the great challenge of properly clarifying the genetic and pathogenic relationships between hantaviruses in the Americas.Keywords
This publication has 31 references indexed in Scilit:
- Hantavirus infection in childrenCurrent Opinion in Pediatrics, 2004
- Hantavirus Pulmonary Syndrome, Southern ChileEmerging Infectious Diseases, 2003
- Serological survey of hantavirus in Jardinopolis county, BrazilJournal of Medical Virology, 2003
- Hantavirus Infection in Humans and Rodents, Northwestern ArgentinaEmerging Infectious Diseases, 2003
- The seroprevalences of anti-hantavirus IgG antibodies among selected Venezuelan populationsPathogens and Global Health, 2003
- Síndrome pulmonar por hantavirus en población infantil. Chile: Regiones IX y X. 1998-2000Revista chilena de infectología, 2000
- Hantavirus Reservoir Hosts Associated with Peridomestic Habitats in ArgentinaEmerging Infectious Diseases, 1999
- Hantavirus Infection in Children in ArgentinaEmerging Infectious Diseases, 1998
- An Unusual Hantavirus Outbreak in Southern Argentina: Person-to-Person Transmission?Emerging Infectious Diseases, 1997
- Genetic Identification of a Hantavirus Associated with an Outbreak of Acute Respiratory IllnessScience, 1993