OBSERVATIONS ON THE FINE STRUCTURE OF MATURE HERPES SIMPLEX VIRUS AND ON THE COMPOSITION OF ITS NUCLEOID
Open Access
- 1 January 1962
- journal article
- Published by Rockefeller University Press in The Journal of Experimental Medicine
- Vol. 115 (1), 1-12
- https://doi.org/10.1084/jem.115.1.1
Abstract
The fine structure and composition of mature herpes virus have been investigated in thin sections by electron microscopy. The virus was grown in cultured HeLa cells and was collected with them. Tests for the biological activity of the infected cultures were included in the first half of the work. Preparations were fixed with both osmium and permanganate, and were embedded either in methacrylate or in aquon, a water-miscible fraction of a commercially available epoxy resin. In further experiments material fixed with permanganate was subjected to the action of specific nucleases or control medium before embedding.This publication has 29 references indexed in Scilit:
- The isolation of type 5 adenovirus using a fluorocarbon; combined morphological and biological studies.1960
- The fine structure and composition of type 5 adenovirus; an integrated electron microscopical and cytochemical study.1960
- The morphology of herpes virusVirology, 1960
- ON THE ROLE OF RIBONUCLEIC ACID IN ANIMAL VIRUS SYNTHESISThe Journal of Experimental Medicine, 1960
- Epoxy Resins in Electron MicroscopyThe Journal of cell biology, 1960
- Observations on the Fine Structure of Type 5 AdenovirusThe Journal of cell biology, 1959
- ELECTRON MICROSCOPIC OBSERVATIONS ON THE DEVELOPMENT OF HERPES SIMPLEX VIRUSThe Journal of Experimental Medicine, 1959
- The ultrastructure of cell membranes and their derivatives.1959
- Staining of Tissue Sections for Electron Microscopy with Heavy MetalsThe Journal of cell biology, 1958
- Changes in nucleic acid content of HeLa cells infected with herpes virusVirology, 1958