Short Term Studies of Effect of Heparin upon Cholesterol Excretion in Man.

Abstract

Heparin, 300 mg daily, was given subcutaneously to 4 humans for 4 days. There was an increase in the daily fecal excretion of bile acids (25-96%) and of digitonin precipitable sterols (19-174%), coincident with a decrease in serum triglycerides and cholesterol. The results indicate that serum triglycerides affect serum cholesterol levels, and that the increased excretion of cholesterol excretion products was a secondary effect resulting from the maintained reduction of circulating triglyceride.