Comorbidities of hidradenitis suppurativa (acne inversa)
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Open Access
- 1 January 2010
- journal article
- Published by Taylor & Francis Ltd in Dermato-Endocrinology
- Vol. 2 (1), 9-16
- https://doi.org/10.4161/derm.2.1.12490
Abstract
Comorbidities of hidradenitis suppurativa (acne inversa) were reviewed by extracting original and review publications included in MEDLINE, EMBASE and COCHRANE libraries using the terms "hidradenitis," "Verneuil" and "acne inversa." Follicular occlusion disorders, inflammatory bowel diseases, especially Crohn's disease, spondylarthropathy, other hyperergic diseases, genetic keratin disorders associated with follicular occlusion and squamous cell carcinoma were the most common hidradenitis suppurativa comorbid diseases. A first classification of these major comorbidities and their possible genetic background reveals a list of chromosome loci and genes, which could be hidradenitis suppurativa candidates. Most of these diseases belong to the group of autoinflammatory disorders, where Th17 cell cytokines seem to play a central role.Keywords
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