Assessing Cognition in Mice
Open Access
- 2 December 2015
- journal article
- research article
- Published by Wiley in Current Protocols in Mouse Biology
- Vol. 5 (4), 331-358
- https://doi.org/10.1002/9780470942390.mo150068
Abstract
Genetically modified mouse models have proven useful to study learning and memory processes and the neurocircuitry and molecular mechanisms involved, as well as to develop therapies for diseases involving cognitive impairment. A variety of tests have been developed to measure cognition in mice, and here we present those established and regularly used in the German Mouse Clinic. The test paradigms have been carefully chosen according to reliability of results and disease relevance of the cognitive functions assessed. Further criteria were time efficiency and ease of application. All tests assess slightly different but also overlapping or interacting aspects of learning and memory so that they can be used to complement each other in a comprehensive assessment of cognitive function. The five protocols described are for spontaneous alternation in the Y-maze, social discrimination, object recognition, automated assessment of learning and memory using the IntelliCage, and olfactory discrimination learning. © 2015 by John Wiley & Sons, Inc.Keywords
This publication has 63 references indexed in Scilit:
- A Broad Phenotypic Screen Identifies Novel Phenotypes Driven by a Single Mutant Allele in Huntington’s Disease CAG Knock-In MicePLOS ONE, 2013
- Crybb2 coding for βB2-crystallin affects sensorimotor gating and hippocampal functionMammalian Genome, 2013
- Genetic dissection of medial habenula-interpeduncular nucleus pathway function in miceFrontiers in Behavioral Neuroscience, 2013
- Comprehensive behavioral phenotyping of Ts65Dn mouse model of Down Syndrome: Activation of β1-adrenergic receptor by xamoterol as a potential cognitive enhancerNeurobiology of Disease, 2011
- When Is the Hippocampus Involved in Recognition Memory?Journal of Neuroscience, 2011
- DJ‐1‐deficient mice show less TH‐positive neurons in the ventral tegmental area and exhibit non‐motoric behavioural impairmentsGenes, Brain and Behavior, 2010
- The Episodic Memory System: Neurocircuitry and DisordersNeuropsychopharmacology, 2009
- Reliability, robustness, and reproducibility in mouse behavioral phenotyping: a cross-laboratory studyPhysiological Genomics, 2008
- Protein phosphatase 1 is a molecular constraint on learning and memoryNature, 2002
- Scopolamine-induced deficits in spontaneous alternation performance: Attenuation with lateral ventricle injections of glucoseBehavioral and Neural Biology, 1992