Cutaneous composite hemangioendothelioma with satellitosis and lymph node metastases
- 15 August 2007
- journal article
- case report
- Published by Wiley in Journal of Cutaneous Pathology
- Vol. 35 (2), 225-230
- https://doi.org/10.1111/j.1600-0560.2007.00781.x
Abstract
The term hemangioendothelioma has been used in recent years to name a heterogeneous group of vascular neoplasms, intermediate in both biological behavior and histopathologic appearance between benign tumors (hemangiomas) and frankly malignant tumors (angiosarcomas). Thus, within the spectrum of hemangioendothelioma have been successively included epithelioid hemangioendothelioma, spindle cell hemangioendothelioma, retiform hemangioendothelioma, kaposiform hemangioendothelioma, polymorphous hemagioendothelioma of the lymph nodes, papillary intralymphatic angioendothelioma (PILA) and composite hemangioendothelioma. The latter is a vascular neoplasm showing varying combinations of benign, low-grade malignant and malignant vascular components. We herein report a case of composite hemangioendothelioma showing a combination of retiform hemangioendothelioma, epithelioid hemangioendothelioma, spindle cell hemangioma and PILA. The neoplasm showed a more aggressive behavior than other reported cases of composite hemangioendothelioma and it developed satellitosis and metastases to the inguinal lymph nodes. Neoplastic cells expressed immunoreactivity for Prox-1, supporting a lymphatic line of differentiation.Keywords
This publication has 16 references indexed in Scilit:
- Differential Prox-1 and CD 31 expression in mucousae, cutaneous and soft tissue vascular lesions and tumorsPathology - Research and Practice, 2005
- Composite cutaneous haemangioendothelioma: case report and review of the literatureClinical and Experimental Dermatology, 2005
- Hipofosfatemia revertida al extirpar hemangioendotelioma compuesto del dedo mayor del pieRevista médica de Chile, 2003
- Composite HemangioendotheliomaThe American Journal of Surgical Pathology, 2000
- Papillary Intralymphatic Angioendothelioma (PILA)The American Journal of Surgical Pathology, 1999
- Polymorphous HemangioendotheliomaThe American Journal of Surgical Pathology, 1997
- Spindle Cell HemangioendotheliomaThe American Journal of Surgical Pathology, 1996
- Spindle cell hemangioendothelioma: A neoplasm associated with Maffucci's syndromeJournal of Cutaneous Pathology, 1995
- Retiform HemangioendotheliomaThe American Journal of Surgical Pathology, 1994
- Spindle cell haemangioendothelioma: a clinicopathological and immunohistochemical study indicative of a non‐neoplastic lesionHistopathology, 1991