The value of diffusion-weighted imaging for monitoring the chemotherapeutic response of osteosarcoma: a comparison between average apparent diffusion coefficient and minimum apparent diffusion coefficient
Open Access
- 19 November 2009
- journal article
- research article
- Published by Springer Science and Business Media LLC in Skeletal Radiology
- Vol. 39 (2), 141-146
- https://doi.org/10.1007/s00256-009-0830-7
Abstract
The objective of this study was to evaluate whether the average apparent diffusion coefficient (ADC) or the minimum ADC is more useful for evaluating the chemotherapeutic response of osteosarcoma. Twenty-two patients with osteosarcoma were examined in this study. Diffusion-weighted (DW) and magnetic resonance (MR) images were performed for all patients before and after chemotherapy. The pre- and post-chemotherapy values were obtained both in the average and minimum ADC. The pre-chemotherapy values of the average ADC and minimum ADC respectively were compared with the post-chemotherapy values. In addition, the ADC ratios ([ADCpost - ADCpre] / ADCpre) were calculated using the average ADC and the minimum ADC. Twenty-two patients with osteosarcomas were divided into two groups, those with a good response to chemotherapy (≥ 90% tumor necrosis, n = 7) and those with a poor response (< 90% tumor necrosis, n = 15). The average ADC ratio and the minimum ADC ratio of the two groups were compared. With both the average ADC and the minimum ADC, post-chemotherapy values were significantly higher than pre-chemotherapy values (P < 0.05). The patients with a good response had a significantly higher minimum ADC ratio than those with a poor response (1.01 ± 0.22 and 0.55 ± 0.29 respectively, P < 0.05). However, with regard to the average ADC ratio, no significant difference was observed between the two groups (0.66 ± 0.18 and 0.46 ± 0.31 respectively, P = 0.19). The minimum ADC is useful for evaluating the chemotherapeutic response of osteosarcoma.Keywords
This publication has 23 references indexed in Scilit:
- Respiratory gated diffusion-weighted imaging of the liver: value of apparent diffusion coefficient measurements in the differentiation between most commonly encountered benign and malignant focal liver lesionsEuropean Radiology, 2007
- Malignant Supratentorial Astrocytoma Treated with Postoperative Radiation Therapy: Prognostic Value of Pretreatment Quantitative Diffusion-weighted MR ImagingRadiology, 2007
- Monitoring therapeutic responses of primary bone tumors by diffusion-weighted image: initial resultsEuropean Radiology, 2006
- OsteosarcomaInvestigative Radiology, 2006
- Diffusion-weighted MR Imaging for Determination of Hepatocellular Carcinoma Response to Yttrium-90 RadioembolizationJournal of Vascular and Interventional Radiology, 2006
- Changes in Water Mobility Measured by Diffusion MRI Predict Response of Metastatic Breast Cancer to ChemotherapyNeoplasia, 2004
- Usefulness of diffusion-weighted MRI with echo-planar technique in the evaluation of cellularity in gliomasJournal of Magnetic Resonance Imaging, 1999
- Osteosarcoma after chemotherapy: evaluation with contrast material-enhanced subtraction MR imaging.Radiology, 1992
- Osteosarcoma: chemotherapy-induced changes at MR imaging.Radiology, 1992
- Primary osteogenic sarcoma: pathologic aspects in 20 patients after treatment with chemotherapy en bloc resection, and prosthetic bone replacement.1977