OUTCOME OF KIDNEY TRANSPLANTATION FROM HIGH-RISK DONORS IS DETERMINED BY BOTH STRUCTURE AND FUNCTION

Abstract

Despite the need to expand the donor pool, it is unclear what parameters should be used. The value of donor renal pathology and calculated creatinine clearance (CrCl) in determining recipient outcome was assessed in 57 kidney transplants from 34 donors in whom pretransplant renal biopsies were performed because of age ≥60, hypertension, and/or vascular disease. We retrospectively compared clinical outcomes in these recipients and 57 control recipients selected to have the same baseline demographics but receiving transplants from low risk donors who were significantly younger (32±13.9 vs. 61±7.3 years) and lighter weight (71±18.1 vs. 84±20.2 kg) than the high-risk donors (P Recipients of high-risk kidneys had a higher incidence of delayed graft function, defined by a P Calculated donor CrCl and donor vascular pathology predict recipient graft function and may be helpful in selecting high-risk donors for single kidney transplantation.