Tissue-specific generation of two preprotachykinin mRNAs from one gene by alternative RNA splicing
- 1 December 1984
- journal article
- research article
- Published by Springer Science and Business Media LLC in Nature
- Vol. 312 (5996), 729-734
- https://doi.org/10.1038/312729a0
Abstract
A novel mammalian neuropeptide, the tachykinin substance K, is specified by a discrete genomic segment. Alternative RNA splicing generates two distinct mRNAs encoding the neuropeptide substance P alone or with substance K from a single preprotachykinin gene. Relative amounts of the mRNAs vary in different tissues, suggesting that the substance K-encoding sequence is regulated in a tissue-specific manner.Keywords
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